Will Taking Yohimbine HCL Down Regulate Beta 2 Receptors?

[mick86]

In brief, I was using Clen and T3, I have been cycling the clen with breaks. I want to try some Yohimbine HCL, seen as how clen work on beta receptors and Yohimbine on Alpha receptors is it far to assume that I can take Yohimbine while on a break from clen with out any risk of affecting the up regulation (recovery) of my beta 2 receptors.

Basically I assuem that you have caffeine, clen ephedrine etc on 1 side of the fence using beta receptors, then Yohimbien on the other using Alpha receptors...? is this correct? I have really only just started looking into this so could have some things backwards :/


Help appreciated

[mick86]

bump

[sixoner]

from the rx list bro.

CLINICAL PHARMACOLOGY
Action

Yocon blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of shorter duration. Yohimbine's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) activity. It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both.

Yohimbine exerts a stimulating action on the mood and may increase anxiety. Such actions have not been adequately studied or related to dosage although they appear to require high doses of the drug. Yohimbine has a mild anti-diuretic action, probably via stimulation of hypothalamic centers and release of posterior pituitary hormone.

Reportedly, Yohimbine exerts no significant influence on cardiac stimulation and other effects mediated by beta-adrenergic receptors. Its effect on blood pressure, if any, would be to lower it; however, no adequate studies are at hand to quantitate this effect in terms of Yohimbine dosage.

[mick86]

thank you very much. anecdotaly I definitely PPEAR 2b holding more water since commencing the yohimbine, up until reading your post I was unable to conclude just why, I actually blamed my sodium/water intake, lol.