Injection and hCG Question

[ZenFitness]

This may be a stupid question, but, after having been on pellets for almost two full months as my first TRT treatment ever in my life, will hCG still have positive effects? In other words, can one be on TRT without hCG for so long that hCG would not have an effect?

I'm going to my doc in a week and a half, and I want to try to convince him to start my on hCG before my pellets wear out. I'm about 95% sure I'll switch over to injections after these wear out.

Second question - what is the difference between a subcutaneous injection and a intramuscular injection (I understand these are the two types on TRT injects)?

Thanks!

[bass]

http://forums.steroid.com/showthread...ou-should-know.

[HealthyMan]

Bass,

I was going to ask the same question. My doctor said I could inject into my delt, thigh, glute or stomach for both HCG and T-Cyp. I've done two doses of the HCG in each delt but was trying to recall if injecting into my stomach area would be more effective versus IM?

[steroid.com 1]

hCG is injected subcutaneously.

Testosterone in injected intramuscular.

[HealthyMan]

gdevine,

What is the consequence of injecting the hCG via IM? Also, is there a reason we don't inject via SC with t-cyp?

[vinceproduction]

I'm actually having the best results with sub q eod test cyp injections. The most stable I've been since starting trt

[bass]

I'm actually having the best results with sub q eod test cyp injections. The most stable I've been since starting trt

me too!

[DanMan250]

Both can be injected either way! You will feel the effects from hCG faster when it is injected IM

[steroid.com 1]

Both can be injected either way! You will feel the effects from hCG faster when it is injected IM

Really?

What do you feel?

[DanMan250]

I get the feeling of wellbeing when I inject hCG IM whereas I don't when I inject it subq. I always use a 30g 1/2 inch dart into my delts for hCG. I have very low fat in the delts so i'm sure it is going IM. Actually a lot guys i've chatted with over the years have experienced the same from IM hCG shots. In the leaflet that comes in the box of Pregnyl it specifically states that it should be injected IM. I don't necessarily agree with this. I've shot it subq and think it works but i think subq probably slows down its release. I actually read a study about 5 years ago comparing subq and IM administration of Pregnyl which found better bioavailability via the IM route. I will have to dig it up.

[kelkel]

Definitely try and find that Dan. We'd love to read it. Very interesting!

[DanMan250]

Here is a study i just found done on obese and non obese women that found better biovavailability in both groups of women when hCG was injected IM. In obese women the bioavailability of hCG was even more pronounced when they injected IM as opposed to SQ. One would assume that these findings would also apply to men.
http://humrep.oxfordjournals.org/con...8/11/2294.full

There is another study that I remember reading several years ago which also found better bioavailability when hCG was injected IM but I will need more time to search for it.

Here is a post from Dr Romeo Mariano (Marianco on Meso-rx) back in 2007 which I think sums it up for us:

"I think both IM and SQ injections are both valid routes.
For fertility protocols, both are equivalent, for example.
IM injections will give you a faster response since muscle has many more blood vessels than subcutaneous fat. The higher peak levels of HCG can then stimulate a higher peak testosterone and estradiol production which in some people gives them a better sense of well-being - however transient that may be depending on the half-life of testosterone and estradiol in that particular person, and the other hormone influences of testosterone and estradiol.
A SQ injection will give you a smaller peak of HCG in the blood but a longer duration of action. This may be useful then when one wants to reduce testicular atrophy by using intermittent HCG injections, rather than daily HCG injections.
It may be worthwhile to try both routes to see what one prefers."

[GirlyGymRat]

Here is a study i just found done on obese and non obese women that found better biovavailability in both groups of women when hCG was injected IM. In obese women the bioavailability of hCG was even more pronounced when they injected IM as opposed to SQ. One would assume that these findings would also apply to men.
http://humrep.oxfordjournals.org/con...8/11/2294.full

There is another study that I remember reading several years ago which also found better bioavailability when hCG was injected IM but I will need more time to search for it.

Here is a post from Dr Romeo Mariano (Marianco on Meso-rx) back in 2007 which I think sums it up for us:

"I think both IM and SQ injections are both valid routes.
For fertility protocols, both are equivalent, for example.
IM injections will give you a faster response since muscle has many more blood vessels than subcutaneous fat. The higher peak levels of HCG can then stimulate a higher peak testosterone and estradiol production which in some people gives them a better sense of well-being - however transient that may be depending on the half-life of testosterone and estradiol in that particular person, and the other hormone influences of testosterone and estradiol.
A SQ injection will give you a smaller peak of HCG in the blood but a longer duration of action. This may be useful then when one wants to reduce testicular atrophy by using intermittent HCG injections, rather than daily HCG injections.
It may be worthwhile to try both routes to see what one prefers."

Dan, thanks for sharing the link for the woman's study on HCG - I find very little information for women so cudos to you for including the information.

Here is the conclusion directly from the link provided: In conclusion, the higher bioavailability of hCG after i.m. injection than after s.c. injection was demonstrated, and a significantly lower bioavailability of hCG was observed in obese women, irrespective of the route of hCG administration. These findings support the advice that obese women should reduce their body weight before embarking on subfertility treatment, as the poor bioavailability of gonadotrophins is one of the many problems that these women might encounter.


In Girly terms, the link speaks to me of inconclusive results since the obese woman were not monitored during injections in to biggy booty muscle which they called glutus maximus...and they had biiiiiiggg bootys. The second thinner location in the deltoids was chosen for s.c., but the fat depth wasn't measured and can't say the injections were beneficial for the fatties. - I can say that cuz I was a fatty once I too did reach a conclusion that i. m. improved for the the skinny gals to improve fertility.

Here is my question. Since test is i. m. and this study indicates improved fertilty for skinny chics i.m., can we conclude that HGH is also improved results if injected i.m.????

[kelkel]

Thanks Dan. Interesting read.

GGR: Good assessment. Thought may be that since HGH is pulsatile in nature would IM have a dramatic effect on the length of it's pulse, therefore reducing its effectiveness? Or none at all...

[GirlyGymRat]

i have read on this site use of hgh to help with recovery of torn muscles/tendonitis by s.c.
I have a shoulder injury and thought I could avoid rehab. Since half life is hours...seems I should be making appts...

[TraceMYD]

I'm about to start taking HCG this week in addition to my TRT of 250mg/week of test E

Regarding injections, is it possible to do IM injections with with the SubQ needles?
If so would the best place to inject would be the delt with a subq needle?

Reason I ask is because I'm pretty sure my script is coming with the subq needles.

THanks

[kelkel]

Trace welcome to the forum. Copy your question and make a thread. You'll get good responses. It's kind of a hijack here. I/we will answer you there.