HGH in the morning & food

[S&S_ShovelHead]

From my reading I've seen it recommended to wait an hour after injection to eat. And that morning injections are the most beneficial.

But following this protocol mean I have to get up earlier to inject then wait an hour before I can have breakfast, which for me is a huge pain in the ass. How have others gone around this? Eat breakfast, wait an hour then poke? Or just poke and eat breakfast within 30 minutes or so?

Does poking first thing in the morning make a huge difference compared to a few hours later after a meal? How much does food affect exogenous HGH?

[Sgt. Hartman]

It's carbs that are the issue around your pinning time because GH can cause insulin resistance in some people. No issue with eating protein or fat meals.

Check your blood sugar after pinning and see how it affects you. GH doesn't noticeably effect my blood sugar levels even with carb meals.

I actually prefer to take it before bed anyway unless I'm doing fasted AM cardio is the only reason I'd take it in morning

[Tron3219]

It's carbs that are the issue around your pinning time because GH can cause insulin resistance in some people. No issue with eating protein or fat meals.

Check your blood sugar after pinning and see how it affects you. GH doesn't noticeably effect my blood sugar levels even with carb meals.

I actually prefer to take it before bed anyway unless I'm doing fasted AM cardio is the only reason I'd take it in morning

I thought carbs blunted gH? Or is it just natural gH secretion it blunts?

-TroN-

[>Good Luck<]

Wa wondering the same things today. When bulking, I barely make it 1.5hours between meals lol. This would seriously effect my eating schedule.

[Tron3219]

Wa wondering the same things today. When bulking, I barely make it 1.5hours between meals lol. This would seriously effect my eating schedule.

It'd b bad ass for me seeing I only eat a handful of carbs a day (30-40g)

-TroN-

[Sgt. Hartman]

I thought carbs blunted gH? Or is it just natural gH secretion it blunts?

-TroN-

That's correct carbs and insulin will inhibit natural gh release whether it be from peptides or natural gh. It's not a coincidence that our biggest natural gh release is after rem sleep when blood sugar and insulin levels are very low.

But it's of no concern when taking rHGH as you're not relying on a natural pulse because you're injecting it.

But there is loads of info showing that gh causes insulin resistance and hyperglycemia. I do NOT want to down play this just because it's not the case for me. It does effect most people especially at higher doses by causing insulin resistance and hyperglycemia. Especially people who are prone to insulin and/or pre-diabetes type issues.

[Tron3219]

That's correct carbs and insulin will inhibit natural gh release whether it be from peptides or natural gh. It's not a coincidence that our biggest natural gh release is after rem sleep when blood sugar and insulin levels are very low.

But it's of no concern when taking rHGH as you're not relying on a natural pulse because you're injecting it.

But there is loads of info showing that gh causes insulin resistance and hyperglycemia. I do NOT want to down play this just because it's not the case for me. It does effect most people especially at higher doses by causing insulin resistance and hyperglycemia. Especially people who are prone to insulin and/or pre-diabetes type issues.

So say me for example, I don't eat many carbs (only post workout). How would this effect my glucose levels with say at 5iu? I can't imagine it would have effect at all because my glucose is always at the low end of the normal spectrum. Except if I took it post wo then it may cause my glucose levels to skyrocket. Is this right?

-TroN-

[Sgt. Hartman]

I'm not gonna speculate how it effects other people. GH has little to no effect on my blood sugar or insulin levels but tbh I believe I'm in the minority.

If you want the opinion from the other end of the spectrum maybe gix will chime in and tell you how he has to take his at night b/c if not it effects his BG all day carbs or not.

There's a bunch of studies on aids patient who actually developed temporary or possibly permanent diabetes from large (I think 18iu a day) gh doses for extended periods.

[Tron3219]

I'm not gonna speculate how it effects other people. GH has little to no effect on my blood sugar or insulin levels but tbh I believe I'm in the minority.

If you want the opinion from the other end of the spectrum maybe gix will chime in and tell you how he has to take his at night b/c if not it effects his BG all day carbs or not.

There's a bunch of studies on aids patient who actually developed temporary or possibly permanent diabetes from large (I think 18iu a day) gh doses for extended periods.

Yeah I understand, I guess it'd have to b one of those experimental things. I'm really intrigued by gH and really want to commit to it, but there's a few things that set me back. One day I suppose...

-TroN-

[Warrior1700]

It's carbs that are the issue around your pinning time because GH can cause insulin resistance in some people. No issue with eating protein or fat meals.

Check your blood sugar after pinning and see how it affects you. GH doesn't noticeably effect my blood sugar levels even with carb meals.

I actually prefer to take it before bed anyway unless I'm doing fasted AM cardio is the only reason I'd take it in morning

Once I start Jin in a couple weeks, I will be pinning in the morning and not eating for an hour, as I read that if we are under mid 50s in age, we should pin in the AM and if over mid 50s pin in the PM.

So should anyone using GH check blood sugar after pinning? Is there a risk that GH causes Diabetes? I haven't read that any where yet. Still researching info about the use of GH on here and internet.

[Sgt. Hartman]

There's a risk of GH causing insulin resistance, it's well documented, especially in people who are prone to having blood sugar issues.

If you're planning on pinning in AM to sustain your natural GH pulse don't bother b/c your elevated IGF and GH levels will suppress your natural GH regardless of when you pin. Just take your GH whenever is convenient.

[Warrior1700]

There's a risk of GH causing insulin resistance, it's well documented, especially in people who are prone to having blood sugar issues.

If you're planning on pinning in AM to sustain your natural GH pulse don't bother b/c your elevated IGF and GH levels will suppress your natural GH regardless of when you pin. Just take your GH whenever is convenient.

Ah ok, thanks, ( I see again where you referenced risk of diabetes under different circumstances, sorry I misspoke about that in my last post)

Is there a way to tell whether that is happening once I start pinning GH? Is that the blood sugar test you mentioned earlier? Or am I thinking too much into this and just take the GH?

I think I decided AM cuz it's possibly the most consistent time for me , and if food is a factor I can hold off eating carbs for an hour after pinning in the AM.

[Buster Brown]

I usually get up about an hour or so before I have to actually get up to take a leak and take my t4 and hgh shot at that time and then go back to bed for an hour.
Somedays, I doesn't work out that way and I found it a pain to wait an hour so I eat, then wait the full hour after to take my shot (not as anxious this way) just my two cents.

[Relax007]

There's a risk of GH causing insulin resistance, it's well documented, especially in people who are prone to having blood sugar issues.

If you're planning on pinning in AM to sustain your natural GH pulse don't bother b/c your elevated IGF and GH levels will suppress your natural GH regardless of when you pin. Just take your GH whenever is convenient.

From my understanding, if you are under the age of 50 you can take GH whenever. It doesn't matter if it is morning or evening? Does doseage matter? For instance, if I was doing 2-4iu/day could I still take GH whenever?

[stirated]

As the above posters have already mention no need to wait a hour before you eat. Load your gh in a slin pin before you go to bed, wrap it in a ice brick and stick it in the bathroom. Then when you get up to have a piss which will usually be about 4am take your shot, this is the absolute best time for those of us under 50.

If this is not possible then first thing in the morning and have a shower then have breakfast that way while your showering gh is doing its thing and if your anything like me it takes you at least 30 mins to wake up in the morning. lol

[Sgt. Hartman]

From my understanding, if you are under the age of 50 you can take GH whenever. It doesn't matter if it is morning or evening? Does doseage matter? For instance, if I was doing 2-4iu/day could I still take GH whenever?

How would being under 50 decrease your chances of GH causing insulin resistance?

[Sgt. Hartman]

From Eli Lilly:

5.4 Glucose Intolerance and Diabetes Mellitus
Treatment with somatropin may decrease insulin sensitivity, particularly at higher doses in susceptible patients. As a result, previously undiagnosed impaired glucose tolerance and overt diabetes mellitus may be unmasked, and new onset type 2 diabetes mellitus has been reported in patients taking somatropin. Therefore, glucose levels should be monitored periodically in all patients treated with somatropin, especially in those with risk factors for diabetes mellitus, such as obesity, Turner syndrome, or a family history of diabetes mellitus. Patients with preexisting type 1 or type 2 diabetes mellitus or impaired glucose tolerance should be monitored closely during somatropin therapy. The doses of antihyperglycemic drugs (e.g., insulin or oral agents) may require adjustment when somatropin therapy is instituted in these patients.

It just makes sense to not have carbs especially high GI carbs around the GH injection window when blood glucose levels would be high at the same time GH levels would be peaking in the blood.

[stirated]

From my understanding, if you are under the age of 50 you can take GH whenever. It doesn't matter if it is morning or evening? Does doseage matter? For instance, if I was doing 2-4iu/day could I still take GH whenever?

From my experience this is not true, take GH in the presence of carbs and to be blunt simple carbs will yield less than positive results. Timing dose indeed matter especially when we are talking muscle building.

[gixxerboy1]

Sgt. Is 100% correct. I'm a dianetic and gh messes with my bg levels like no other. I do my shot right before bed

[MuscleInk]

From Eli Lilly:

5.4 Glucose Intolerance and Diabetes Mellitus
Treatment with somatropin may decrease insulin sensitivity, particularly at higher doses in susceptible patients. As a result, previously undiagnosed impaired glucose tolerance and overt diabetes mellitus may be unmasked, and new onset type 2 diabetes mellitus has been reported in patients taking somatropin. Therefore, glucose levels should be monitored periodically in all patients treated with somatropin, especially in those with risk factors for diabetes mellitus, such as obesity, Turner syndrome, or a family history of diabetes mellitus. Patients with preexisting type 1 or type 2 diabetes mellitus or impaired glucose tolerance should be monitored closely during somatropin therapy. The doses of antihyperglycemic drugs (e.g., insulin or oral agents) may require adjustment when somatropin therapy is instituted in these patients.

It just makes sense to not have carbs especially high GI carbs around the GH injection window when blood glucose levels would be high at the same time GH levels would be peaking in the blood.

On the money Sgt. I advise my patients taking IGF-1 or GH to dose before bed or 60-90 mins before their first meal for the very reasons you referenced here.

[marcus300]

Sgt looks like he's fully took care of this thread, great advice

[Deanruss]

HGH and insulin resistance is something to be taken seriously.When I first started doing HGH I had no idea it could cause insulin resistance and just did it when I finished work before,during and after food.A few times I noticed I was going a bit dizzy then 1 time I nearly passed out.After this I googled it and worked out what the problem was but for the next 2 weeks I was going dizzy when I was eating carbs.Scared the life out of me! Thought I could have caused permanent diabetes but the symptoms eased off.I now pin it early morning when I get up for the toilet and have never had any problems.

[Deanruss]

[QUOTE="Deanruss"]HGH and insulin resistance is something to be taken seriously.When I first started doing HGH I had no idea it could cause insulin resistance and just did it when I finished work before,during and after food at just 4iu.A few times I noticed I was going a bit dizzy then 1 time I nearly passed out.After this I googled it and worked out what the problem was but for the next 2 weeks I was going dizzy when I was eating carbs.Scared the life out of me! Thought I could have caused permanent diabetes but the symptoms eased off.I now pin it early morning when I get up for the toilet and have never had any problems.

[tjax03]

From Eli Lilly:

5.4 Glucose Intolerance and Diabetes Mellitus
Treatment with somatropin may decrease insulin sensitivity, particularly at higher doses in susceptible patients. As a result, previously undiagnosed impaired glucose tolerance and overt diabetes mellitus may be unmasked, and new onset type 2 diabetes mellitus has been reported in patients taking somatropin. Therefore, glucose levels should be monitored periodically in all patients treated with somatropin, especially in those with risk factors for diabetes mellitus, such as obesity, Turner syndrome, or a family history of diabetes mellitus. Patients with preexisting type 1 or type 2 diabetes mellitus or impaired glucose tolerance should be monitored closely during somatropin therapy. The doses of antihyperglycemic drugs (e.g., insulin or oral agents) may require adjustment when somatropin therapy is instituted in these patients.

It just makes sense to not have carbs especially high GI carbs around the GH injection window when blood glucose levels would be high at the same time GH levels would be peaking in the blood.

One thing that I would like to throw into this discussion that I do not believe has been mentioned yet are the effects of an insulin independent mechanism for glucose uptake into skeletal muscle. This comes to mind after reading Hartman's posting of this Eli Lilly info piece. Basically, it suggests that certain populations may be at a higher risk of diabetes in response to GH therapy (the obese, strong family history, inactive, etc). Now some of you may know this, and some may not, but the primary transporter for the uptake of glucose into both adipose (fat) and skeletal muscle cells is called GLUT4. It is a cell membrane bound protein that is regulated by two primary factors. The first is insulin. When insulin levels increase in response to a meal, GLUT4 molecules, which have been synthesized and stored within the cell, are then transferred to the cell surface/membrane, where they function to transport glucose into the cells for conversion to energy etc. In the case of insulin resistance, as seen in response to GH therapy, insulin will have less of an effect on increasing the amount of GLUT4 at the cell surface, allowing it to remain within the cell where it is useless. This has the effect of increasing blood glucose, and in combination with other factors, may result in the development of diabetes. However, GLUT4 within skeletal muscle is also regulated solely by the contraction of the muscle itself. I'm unsure of the exact mechanism, but basically when we flex our muscles, the structure of the muscle cell deforms slightly, which results in increased cell surface GLUT4 expression. What does all this really mean to you all? Well, if you are lifting weights consistently, you will be getting decent GLUT4 expression on the cell surface due to the previously mentioned mechanism. This will help to reduce any increase in blood sugar levels caused by GH use. Furthermore, and perhaps more desirable, this mechanism will result in increased shuttling of glucose into the muscles where we want it, while simultaneously reducing shuttling into adipose tissue. This is because the GLUT4 transport into fat cells is solely dependent on insulin sensitivity unlike the muscle cells where we can rely on the cellular pathways triggered by muscle contraction to aid in glucose uptake. I hope you all find this helpful in aiding you understanding and interesting.

[tjax03]

One thing that I would like to throw into this discussion that I do not believe has been mentioned yet are the effects of an insulin independent mechanism for glucose uptake into skeletal muscle. This comes to mind after reading Hartman's posting of this Eli Lilly info piece. Basically, it suggests that certain populations may be at a higher risk of diabetes in response to GH therapy (the obese, strong family history, inactive, etc). Now some of you may know this, and some may not, but the primary transporter for the uptake of glucose into both adipose (fat) and skeletal muscle cells is called GLUT4. It is a cell membrane bound protein that is regulated by two primary factors. The first is insulin. When insulin levels increase in response to a meal, GLUT4 molecules, which have been synthesized and stored within the cell, are then transferred to the cell surface/membrane, where they function to transport glucose into the cells for conversion to energy etc. In the case of insulin resistance, as seen in response to GH therapy, insulin will have less of an effect on increasing the amount of GLUT4 at the cell surface, allowing it to remain within the cell where it is useless. This has the effect of increasing blood glucose, and in combination with other factors, may result in the development of diabetes. However, GLUT4 within skeletal muscle is also regulated solely by the contraction of the muscle itself. I'm unsure of the exact mechanism, but basically when we flex our muscles, the structure of the muscle cell deforms slightly, which results in increased cell surface GLUT4 expression. What does all this really mean to you all? Well, if you are lifting weights consistently, you will be getting decent GLUT4 expression on the cell surface due to the previously mentioned mechanism. This will help to reduce any increase in blood sugar levels caused by GH use. Furthermore, and perhaps more desirable, this mechanism will result in increased shuttling of glucose into the muscles where we want it, while simultaneously reducing shuttling into adipose tissue. This is because the GLUT4 transport into fat cells is solely dependent on insulin sensitivity unlike the muscle cells where we can rely on the cellular pathways triggered by muscle contraction to aid in glucose uptake. I hope you all find this helpful in aiding you understanding and interesting.

One thing I forgot to add is that on very high doses of GH, this contraction mediated muscle uptake will most likely not be enough to compensate for insulin resistance. However for moderate dosing, consistent weight training and careful dieting should do alot to keep blood sugar from getting out of hand. I'm not going to say it will never get over 100, but within that general range is highly likely.

[OnTheSauce]

He'll I stay between 90-100 all the time anyway

[gixxerboy1]

He'll I stay between 90-100 all the time anyway

thats a good range, but doesnt mean your body isnt pumping out more insulin to keep you there