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Thread: Nonerectogenic benefits of PDE5 inhibitors

  1. #1
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    In the past week, I've been asked several times about the benefits of phosphodiesterase-5 inhibitors such as Sildenafil, vardenafil, and tadalafil beyond their typically prescribed usage for erectile dysfunction. I know there have been many discussions on this topic and I certainly don't want to regurgitate much of the great information already discussed or start a redundant thread, but for general information, I've summarized some of the currently known benefits:

    - BPH
    - hypertension
    - certain GI disorders
    - improved sperm motility
    - genital blood flow (ED)
    - endothelial elasticity
    - increased exercise endurance

    Feel free to comment or contribute.
    Last edited by MuscleInk; 03-19-2013 at 09:40 PM.

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    Uhmmmmm.....and they are?

    Opps...guess I was a little late!

    -TroN-

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    Quote Originally Posted by MuscleInk
    In the past week, I've been asked several times about the benefits of phosphodiesterase-5 inhibitors such as Sildenafil, vardenafil, and tadalafil beyond their typically prescribed usage for erectile dysfunction. I know there have been many discussions on this topic and I certainly don't want to regurgitate much of the great information already discussed or start a redundant thread, but for general information, I've summarized some of the currently known benefits:

    - BPH
    - hypertension
    - certain GI disorders
    - improved sperm motility
    - genital blood flow (ED)
    - endothelial elasticity
    - increased exercise endurance

    Take at a higher dose it causes me to have back to back orgasms

    Feel free to comment or contribute.
    -TroN-

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    Quote Originally Posted by Tron3219
    Uhmmmmm.....and they are?

    Opps...guess I was a little late!

    -TroN-
    Lol.....ya sorry. Stupid phone. I bet the suspense was just killing ya! Lol

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    Quote Originally Posted by Tron3219

    -TroN-
    You get back orgasms because you're a nympho.

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    increased pumps and vascularity, or so i heard.

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    Quote Originally Posted by AD
    increased pumps and vascularity, or so i heard.
    Yup, improved endothelial elasticity. I've tried dosing 5mg 30mins before lifting. It "felt" like better pumps but that could be half true/half placebo.

    I know a few guys in SoCal that take Viagra as part of a preworkout for the exact reason.

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    Quote Originally Posted by MuscleInk View Post
    Yup, improved endothelial elasticity. I've tried dosing 5mg 30mins before lifting. It "felt" like better pumps but that could be half true/half placebo.

    I know a few guys in SoCal that take Viagra as part of a preworkout for the exact reason.
    but you know me, i always feel a little uncomfortable when promoting any drug for its off-label uses...
    so for the records, i only use them for one reason. cos i am an old man...lol old but horny.

  9. #9
    I wanna rx of cialis so bad for these reasons....

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    Quote Originally Posted by MuscleInk

    You get back orgasms because you're a nympho.
    Fair enough

    -TroN-

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    Quote Originally Posted by Perseverance1
    I wanna rx of cialis so bad for these reasons....
    Ar-r offers liquid-C. I've used it once and do keep a few bottles on hand but I am able to get Pharma grade Cialis easily. The Ar-r oral solution tastes good and many guys here swear by it! You might want to give it a try.

  12. #12
    Quote Originally Posted by MuscleInk View Post
    Ar-r offers liquid-C. I've used it once and do keep a few bottles on hand but I am able to get Pharma grade Cialis easily. The Ar-r oral solution tastes good and many guys here swear by it! You might want to give it a try.
    I actually tried to buy a few bottles during that 60% sale (along with a ton of other stuff) but it wouldn't go through....now in just waiting for them to give me that code so I can pull the trigger.

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    Quote Originally Posted by Perseverance1

    I actually tried to buy a few bottles during that 60% sale (along with a ton of other stuff) but it wouldn't go through....now in just waiting for them to give me that code so I can pull the trigger.
    Ok, well it'll be worth the wait!

  14. #14
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    It helps with vascularity? Shiat then I'm getting some...
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    Quote Originally Posted by kelkel
    It helps with vascularity? Shiat then I'm getting some...
    How could you possibly be any more vascular!?!

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    Dont you guys get worried about being in a constant state of arousal? I still feel like Im 17 even when not on cycle, I just have more control now than back then. I couldnt imagine being "primed" 24/7 for a few other benefits.

  17. #17
    Quote Originally Posted by Knockout_Power View Post
    Dont you guys get worried about being in a constant state of arousal? I still feel like Im 17 even when not on cycle, I just have more control now than back then. I couldnt imagine being "primed" 24/7 for a few other benefits.
    I'm already in a constant state of arousal...at least this way I'll get some benefits haha.

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    Quote Originally Posted by Knockout_Power
    Dont you guys get worried about being in a constant state of arousal? I still feel like Im 17 even when not on cycle, I just have more control now than back then. I couldnt imagine being "primed" 24/7 for a few other benefits.
    No, not really. Tadalafil isn't like Bremelanotide (pt-141) which is designed to enhance libido through CNS activation. Cialis works by increasing the availability of nitric oxide from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Increased cGMP relaxes smooth muscle and enhances blood flow to the corpus cavernosum of the penis allowing for better engorgement to promote firmer erections. At 5-10mg the effect mostly occurs during "stimulation" as opposed to randomly.

    Anecdotally I feel as though the increased NO and endothelial elasticity causes better pumps during work outs but Im not walking around with a stiffy while I lift.

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    Quote Originally Posted by MuscleInk View Post
    No, not really. Tadalafil isn't like Bremelanotide (pt-141) which is designed to enhance libido through CNS activation. Cialis works by increasing the availability of nitric oxide from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Increased cGMP relaxes smooth muscle and enhances blood flow to the corpus cavernosum of the penis allowing for better engorgement to promote firmer erections. At 5-10mg the effect mostly occurs during "stimulation" as opposed to randomly.

    Anecdotally I feel as though the increased NO and endothelial elasticity causes better pumps during work outs but Im not walking around with a stiffy while I lift.
    Interesting... cause I would hate to have to go stand in the corner after each set... that gets a bit annoying by the 2nd or 3rd time.

    Some of the muscle relaxant properties sound nice though.

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    Quote Originally Posted by Knockout_Power

    Interesting... cause I would hate to have to go stand in the corner after each set... that gets a bit annoying by the 2nd or 3rd time.

    Some of the muscle relaxant properties sound nice though.
    You never know. It might get the attention of the ladies in the gym.....or you'll scare the heck out of them! Lol

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    Quote Originally Posted by MuscleInk View Post
    In the past week, I've been asked several times about the benefits of phosphodiesterase-5 inhibitors such as Sildenafil, vardenafil, and tadalafil beyond their typically prescribed usage for erectile dysfunction. I know there have been many discussions on this topic and I certainly don't want to regurgitate much of the great information already discussed or start a redundant thread, but for general information, I've summarized some of the currently known benefits:

    - BPH
    - hypertension
    - certain GI disorders
    - improved sperm motility
    - genital blood flow (ED)
    - endothelial elasticity
    - increased exercise endurance

    Feel free to comment or contribute.
    Excellent post, as usual MI. Btw, i had to Google 'endothelial elasticity'. I get a little anxious around those 12 cylinder words..lol

    Quote Originally Posted by Perseverance1 View Post
    I wanna rx of cialis so bad for these reasons....
    My Doc just gave me, (that's right, gave, as in freeee) 16 boxes of 20mg Cialis.

    Quote Originally Posted by Perseverance1 View Post
    I actually tried to buy a few bottles during that 60% sale (along with a ton of other stuff) but it wouldn't go through....now in just waiting for them to give me that code so I can pull the trigger.
    You dont have a code yet? Send a PM to Lion. He'll straighten you out bro.

  22. #22
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    Just like a "Time Out" when you're a kid!
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    Quote Originally Posted by MickeyKnox

    Excellent post, as usual MI. Btw, i had to Google 'endothelial elasticity'. I get a little anxious around those 12 cylinder words..lol

    My Doc just gave me, (that's right, gave, as in freeee) 16 boxes of 20mg Cialis.

    You dont have a code yet? Send a PM to Lion. He'll straighten you out bro.
    Thanks bro. That was an abbreviated post. The first was longer so I edited it and my phone kicked me out and I had to retype the darn thing!

    I ordered a one year supply (daily dose) of Cialis from the pharmacy yesterday. Should last me about three months.

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    Quote Originally Posted by kelkel View Post
    It helps with vascularity? Shiat then I'm getting some...
    You're super vascularrrrr

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    My pharmacy sends me a bottle of 180 5mg tabs every 3 months like clockwork. Big ars bottle...nice.
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    Quote Originally Posted by MuscleInk View Post
    Thanks bro. That was an abbreviated post. The first was longer so I edited it and my phone kicked me out and I had to retype the darn thing!

    I ordered a one year supply (daily dose) of Cialis from the pharmacy yesterday. Should last me about three months.
    Braggart..lol

    Quote Originally Posted by kelkel View Post
    My pharmacy sends me a bottle of 180 5mg tabs every 3 months like clockwork. Big ars bottle...nice.
    Kel, the Docs ups here so behind i often think of calling my Doc Fred Flintstone.

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