Quote Originally Posted by Low Testosterone View Post
Injectable testosterone has the highest success rate, where as transdermals have a 20% failure rate. Next time you see an AndroGel commercial, they will verbally mention it or it will be in the small print at the bottom of the screen. Of course, that leaves an 80% success rate and on the surface that doesn't sound too bad, but it sounds much better than it is. Of those that it works well for, many find that they adapt or what's often referred to as "Transdermal Fatigue." They simply don't absorb it well anymore - there's nothing wrong with the testosterone itself, it's just not absorbing. So they end up adding larger and larger doses and many doctors stand there scratching their head. This cannot happen with injectable testosterone. And then there are some men that will find transdermals work well indefinitely.

Pellets, convenience is the appeal, no doubt. The downside, primary - you have very little control. The number of pellets may not be enough or could be too much. With transdermals and injectables you can easily make adjustments when and if needed.
Hi,
Do you know what causes the transdermal fatigue? I was reading that it's thyroid issues that causes thickening of the skin, which leads to poor absorption.