link...http://www.popline.org/docs/0231/746377.htmlOriginally Posted by Swifto
Abstract
"The effect of mesterolone (1 alpha-methyl-5 alpha-dihydrotestosterone) administration to 10 normal men, aged 24-27 years, on the pituitary-testicular function was investigated. No effect on the plasma levels of interstitial cell-stimulating hormone (ICSH) and follicle stimulating hormone could be detected. After 4 weeks on 75 mg mesterolone/day a significant (p < .01) drop in the mean level of testosterone was observed, 5.2 to 4 ng/ml. After another 4 weeks on 150 mg/day a further decrease to 3.5 ng/ml was found. During mesterolone administration the protein binding of testosterone was significantly (p < .0025) reduced and it appeared that the level of free (nonprotein bound) testosterone in diluted plasma remained unchanged, .37 and .41 ng/ml, before and after mesterolone administration, respectively. These results suggest that mesterolone given in doses of 75 and 150 mg/day to normal men does not suppress the pituitary ICSH production or the testicular testosterone production."
I know there are various studies out there and the topic is "debatable" but evidence suggest a slight decrease in endogenous testosterone production.
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