You can shove em up your ass and they'll absorb even better and avoid the first pass that way too. With that said, I would just swallow the damn things.
Oh so wrong my friend!
Any compound inserted into ur ass will be absorped into the bloodstream via the Ileocolic Vein/Inferior Mesenteric Vein ... Which drains into the Liver, same as the rest of the intestinal tract, via the Hepatic Portal Vein....