Aromasin vs. Arimidex ??

[legobricks]

Ok cool thanx merc! One question tho, why is letro so discouraged during PCT? If your estrogen is stopped too much then doesnt it effect your libido, mood, gains, etc? Just curious if letro is too strong compared to aromasin and adex. Also is letro a type II AI?

[magic32]

Yeah, what Merc said.

Ok cool thanx merc! One question tho, why is letro so discouraged during PCT? If your estrogen is stopped too much then doesnt it effect your libido, mood, gains, etc?
TRUE, SIDE EFFECTS ARE ONE REASON FOR THE DISCOURAGEMENT, BUT ALSO BECAUSE PCT IS THE TIME TO RESTORE HORMONAL BALANCE NOT DISRUPT IT FURTHER. THIS MAKES SERMS IDEAL AS THEY SIMPLY PREVENT ESTRO ATTACHMENT (DUE TO RECEPTOR PREFERENCE) WHILE PERMITTING FREE-ESTRO TO REMAIN IN THE BLOODSTREAM AT NORMAL LEVELS.

Just curious if letro is too strong compared to aromasin and adex.
THE ALLIANCES ABOVE ARE INCORRECT. ADEX IS THE WEAKER THE OTHER TWO ARE SYNONYMOUSLY STRONG.

Surprisingly, not a lot of people seem to know this, but both Letro and Mase are about even strength-wise, e.g. in their ability to reduce estrogen.
Mase:

“Plasma estrogen (estradiol, estrone, and estrone sulfate) seen starting at a 5-mg daily dose of exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose.”
http://www.pfizer.com/files/products/uspi_aromasin.pdf & http://www.fda.gov/cder/foi/label/20...753s006lbl.pdf (SEE: Pharmacodynamics)

And at a percentage highly commensurate to that is Letro’s rapid, dose dependent (to reach optimal prevention) suppression rate…

”Femara suppress plasma concentrations of estradiol, estrone, and estrone sulfate by 75%-95% from baseline with maximal suppression achieved within two-three days.” http://www.pharma.us.novartis.com/pr...pdf/Femara.pdf (SEE: Pharmacodynamics)

This also explains why neither is recommended during cycle unless gyno appears and the user prefers not to wait post-cycle (which is acceptable due to rapid response time, and obliteration of symptoms even after elapsed time).

So there you have it.

[Merc..]

Yeah, what Merc said.



Surprisingly, not a lot of people seem to know this, but both Letro and Mase are about even strength-wise, e.g. in their ability to reduce estrogen.
Mase:

And at a percentage highly commensurate to that is Letro’s rapid, dose dependent (to reach optimal prevention) suppression rate…


This also explains why neither is recommended during cycle unless gyno appears and the user prefers not to wait post-cycle (which is acceptable due to rapid response time, and obliteration of symptoms even after elapsed time).

So there you have it.

Great post ....




Merc.