roberts pct question - HCG?

[Merc..]

hcg wont actually do anything for increasing test production.. infact it actually supresses.

only good for increasing testicular axis, and nolva or clomid will kick start the natty production.

Yea HCG does increase test production ..

LH binds to receptors on leydig cells which stimulates test production ..

Also , yes HCG is suppressive ( on 17 ohp), but using nolva in conjunction with HCG will block its suppressive nature...

See this study

Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.Smals AG, Pieters GF, Drayer JI, Boers GH, Benraad TJ, Kloppenborg PW.
Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.

PMID: 7419679 [PubMed - indexed for MEDLINE]


Merc.

[shifty_git]

Yea HCG does increase test production ..

LH binds to receptors on leydig cells which stimulates test production ..

Also , yes HCG is suppressive ( on 17 ohp), but using nolva in conjunction with HCG will block its suppressive nature...

See this study

Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone accumulation in normal men.Smals AG, Pieters GF, Drayer JI, Boers GH, Benraad TJ, Kloppenborg PW.
Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). These data indirectly suggest that, in man, the hCG-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.

PMID: 7419679 [PubMed - indexed for MEDLINE]


Merc.

edited ma post as was taking it in the context of using hcg alone.