Is Clenbuterol really that dangerous?

[hugovsilva]

Also

Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles.

Burniston JG, Clark WA, Tan LB, Goldspink DF.

Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK.

Muscle growth in response to large doses (milligrams per kilogram) of beta(2)-adrenergic receptor agonists has been reported consistently. However, such doses may also induce myocyte death in the heart and skeletal muscles and hence may not be safe doses for humans. We report the hypertrophic and myotoxic effects of different doses of clenbuterol. Rats were infused with clenbuterol (range, 1 mug to 1 mg.kg(-1)) for 14 days. Muscle protein content, myofiber cross-sectional area, and myocyte death were then investigated. Infusions of >/=10 mug.kg(-1).d(-1) of clenbuterol significantly (P < 0.05) increased the protein content of the heart (12%-15%), soleus (12%), plantaris (18%-29%), and tibialis anterior (11%-22%) muscles, with concomitant myofiber hypertrophy. Larger doses (100 mug or 1 mg) induced significant (P < 0.05) myocyte death in the soleus (peak 0.2 +/- 0.1% apoptosis), diaphragm (peak 0.15 +/- 0.1% apoptosis), and plantaris (peak 0.3 +/- 0.05% necrosis), and significantly increased the area fraction of collagen in the myocardium. These data show that the low dose of 10 mug.kg(-1).d(-1) can be used in rats to investigate the anabolic effects of clenbuterol in the absence of myocyte death. Muscle Nerve, 2006.



So in this one it shows heart cell death at 10mcg per Kg..

Merc.

(100 mug or 1 mg) I did not know this unit (mug) but from this it seem like 1/100 of a mg or 10mcg.

So if in rats it was needed more than 10 mug/kg to see myocyte death, this this still means a dosage of 100mcg/kg.

This "means" that a standard bodybuilder of 90kg would have to take around 9000mcg (9 mg) to see myocyte death. This of course is just speculation since the studies were conducted in mice.

[Merc..]

(100 mug or 1 mg) I did not know this unit (mug) but from this it seem like 1/100 of a mg or 10mcg.

So if in rats it was needed more than 10 mug/kg to see myocyte death, this this still means a dosage of 100mcg/kg.

This "means" that a standard bodybuilder of 90kg would have to take around 900mcg to see myocyte death. This of course is just speculation since the studies were conducted in mice.

........

[solidA]

not worth it
its not even dramatic results

[hugovsilva]

........

I corrected my post because the lowest dosage to cause myocyte death was not 900 mcg but 9000 mcg or 9 mg.