Quote Originally Posted by Atomini View Post
Nope, receptors do not downregulate nor do they "saturate" as it was once commonly theorized. A recent study has disproven this. They discovered that muscle cells, in the presence of supraphysiological amounts of androgens actually grow MORE receptors even FASTER on the muscle cells. So now the only logical reason why gains stop and/or slow down on cycle is because of the other proteins and counter-hormones the body produces to counter the high amounts of exogenous androgens (stuff like SHBG, cortisol, estrogen, etc.), not because of 'receptor saturation'.

So yes, your body does become resistant to the muscle-building effects of AAS. This is one of the many reasons why we cycle.
+1... I wonder if u regulated all of these during ur cycle u would keep growing. SHBG can be regulated by provirion, estrogen has countless things, same with cortisol. HMM???