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Thread: Deca Dosage? Advice Needed

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  1. #1
    Join Date
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    my thinking is.. nolvadex's effect on progesterone is irrelevant in terms of gyno.
    progesterone will not cause gyno in the absence of estrogen,.if you use nolvadex the ER is blocked in breast tissue so the progesterone cant become a problem anyway.

  2. #2
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    Quote Originally Posted by Mulciber View Post
    my thinking is.. nolvadex's effect on progesterone is irrelevant in terms of gyno.
    progesterone will not cause gyno in the absence of estrogen,.if you use nolvadex the ER is blocked in breast tissue so the progesterone cant become a problem anyway.
    But what about the progesterone receptors?

  3. #3
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    Just to reiterate your point on a lack of estrogen means no progesterone issues.
    Estrogen is necessary to induce the progesterone receptors. When no binding hormone is present the carboxyl terminal inhibits transcription. Binding to a hormone induces a structural change that removes the inhibitory action. Progesterone antagonists prevent the structural reconfiguration.
    Is this what you wanted to hear bro.

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