^^^ mmm i cant speak directly to anabolics and recptor down regulation. I can however, based on what I do for a living, state it is a very real issue and concern when it comes to a great % of pharmaceutical medications. The continuing need to increase dosages of certain meds because of this is an ongoing area of concern because many medications ,to a certain degree, are toxic or exhibit increased unwanted side effects as dosages increase. Anyway....i'm not so sure about it being of no concern ...based on steroids mechanism of action in the body (receptor site binding) ...i would more wonder how long it takes....
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