Additional supplements/ vitamins etc while on cycle ?

[drummerofgod87]

Cycling creatine would be like cycling vitamins. It's not like the body downregulates any activity in the body thusly reducing the body's sensitivity to creatine.

[Dinosaur]

Cycling creatine would be like cycling vitamins. It's not like the body downregulates any activity in the body thusly reducing the body's sensitivity to creatine.

i disagree to that statement you made about creatine unless you have a real statistic that proves me wrong other wise.

[drummerofgod87]

i disagree to that statement you made about creatine unless you have a real statistic that proves me wrong other wise.

Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans

Mark Tarnopolsky1 Contact Information, Gianni Parise2, Min-H Fu Surname3, Andrea Brose2, Andrew Prasad3, Oliver Speer4 and Theo Wallimann4
(1) Department of Medicine (Neurology and Rehabilitation), Department of Kinesiology, McMaster University, 1200 Main St. W., Hamilton, Ontario, Canada
(2) Department of Kinesiology, McMaster University, 1200 Main St. W., Hamilton, Ontario, Canada
(3) Department of Medicine (Neurology and Rehabilitation), McMaster University, 1200 Main St. W., Hamilton, Ontario, Canada
(4) Institute of Cell Biology (Swiss Federal Institute of Technology), Hoenggerberg, Zurich, Switzerland

Abstract Animal studies have shown that supra-physiological creatine monohydrate (Cr-mH) supplementation for 3 months reduced skeletal muscle creatine transporter (CRT) content. The doses of Cr-mH (1–2 g/kg/day) used in these studies were between 5 and 10 times those usually used in human studies, and it is unclear whether a down-regulation of CRT would occur in humans at the recommended doses of 0.1–0.2 g/kg/day. We measured CRT, and citrate synthase (CS) protein content using Western blotting before and after 2 months of Cr-mH supplementation and weight training in young men (N = 11 Cr-mH (0.125 g/kg/day); N = 8 placebo). CRT and CS were also measured before and after 4 months of Cr-mH supplementation and weight training in elderly (> 65 years) men and women (N = 14 Cr-mH (0.075 g/kg/day); N = 14 placebo). Finally, CRT mRNA was measured using competitive RT-PCR before and after 8–9 days of Cr-mH loading in young men and women (N = 14, CR-mH (mean = 0.18 g/kg/day); N = 13, PL). Total creatine content was significantly elevated after the Cr-mH supplementation period as compared to placebo in each of the studies. Neither Cr-mH supplementation, nor exercise training resulted in measurable alterations in CRT protein content and acute Cr-mH loading did not alter CRT mRNA. There were no gender differences in CRT mRNA or total creatine content in the young subjects and no gender differences in total creatine content or CRT protein content in the elderly subjects. Weight training in young men did not increase CS protein content, however, in the elderly there was a significant increase in CS protein content after exercise training (p < 0.05). These results demonstrated that Cr-mH supplementation during weight training resulted in increases in skeletal muscle total creatine without reductions in CRT protein and acute Cr-mH loading did not decrease CRT mRNA content.

I hope this was satisfying.