Knowledgeable Member
Ironically, I have a buddy who developed gyno from a pro hormone (yes, a pro hormone) and I just started him on letro and will follow the letro with Raloxifene (Evista) to prevent estrogen rebound. I'm curious to see how things go and have faith that this will cure his problem!Originally Posted by Swifto
Banned- Scammer!
It seems Letro and SERMs dont like each other.
Tamoxifen and Letro dont fair well together as Tamox will reduce the amount of Letro active in the body.
This may well also be the case with Raloxifene too. Its something worth thinking about, although there are no studies for other SERMs (only Tamoxifen), there is a high chance Raloxifene will have the same, or similar, effect IMHO. There very similar structurely.
I'd go with Aromasin/Ralox. Or ATD/Ralox, but kiss goodbye to your sex drive for a bit.
Post Cycle Extraordinaire~GOT PCT?
That does seem to be the case bro. Im sure youll like this. Found it a while ago and helo onto it.
Nolva can decrease plasma levels of Letro.
Drug and hormone interactions of aromatase inhibitors.
Dowsett M.
Academic Department of Biochemistry, The Royal Marsden NHS Trust, London, UK.
The clinical development of aromatase inhibitors has been largely confined to postmenopausal breast cancer patients and strongly guided by pharmacological data. Comparative oestrogen suppression has been helpful in circumstances in which at least one of the comparitors has caused substantially non-maximal aromatase inhibition. However, the triazole inhibitors, letrozole and anastrozole, and the steroidal inhibitor, exemestane, all cause >95% inhibition. Comparisons between these drugs therefore require more sensitive approaches such as the direct measurement of enzyme activity by isotopic means. None of these three agents has significant effects on other endocrine pathways at its clinically applied doses. Pharmacokinetic analyses of the combination of tamoxifen and letrozole have revealed that these drugs interact, resulting in letrozole concentrations approximately 35-40% lower than when letrozole is used alone.
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
And like i said before ill be adding more revisions. Hit me up with a PM about the Raloxifene Switfo, as i dont know as much as i should i feel. Im sure you could fill me in so that i can add it to the thread.
Knowledgeable Member
I understand that running letro and tamox together is not a good idea but what is wrong with running the letro (by itself) to reduce/eliminate the gyno, and then starting the Tamox or Ralox the day after you have discontinued the use of letro in order to prevent estrogen rebound? Is it because the letro would still be present in the blood stream? I am a little confused here. Also, note that this protocol is being preformed off cycle.
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