benadryl does nothing for clenbuterol.
Now that I have your attention I wanted to get some adult discussion on whether or not taking benadryl every 3 weeks will for sure upregulate the beta 2 receptors so clen will work better.
Here's the study below I copied and a few of my doubts as to why I do not think benadryl will help clenbuterol. I hope we can get some good feedback on this topic. I'll start things by adding my comments in red and let others elaborate. Please keep it civil. I think Anthony Roberts came up with this idea and it is not being accepted by mainstream bodybuilders in my area.
Clenbuterol can also cause a downregulation in testicular androgen receptors and in pulmonary, cardiac and central nervous system beta-adrenergic receptors(6.) possibly making steroids less effective (if there is androgen receptor downregulation elsewhere as well, then it´s highly probable) while you are on clen; but definitely making clen less effective as time goes on and you keep taking it. To counteract this, you can take some ketotifen every 3rd or 4th week that you remain on clen. It´s a prescription anti-histimines, so it´ll make you drowsy (take before bedtime). Basically, the way this works is to reduce beta-2 receptor activity, and restore receptor function (15).
Another option, if you are worried about receptor downgrade, is taking Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week). Benadryl is sold as an anti-histamine in the United States, and/or a sleep aid elsewhere in the world. However, Beta receptors are embedded in the cell´s outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors. Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes them as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitization of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.
Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.
Ergo, Benadryl slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly. (7). This will allow you to use clen for much longer and it´ll still have the same effects. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2´s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation (16), and thus upregulating your beta-receptors.
MY RESPONSE TO THE ABOVE ARTICLE BELOW IN RED:
Methylation of phospholipids? Beta 1 and 2 receptors operate through a G-s transmembrane protein receptor which when activated by binding of a ligand results in stimulating Adenylate Cyclase. This 2nd messenger cascade converts ATP --> cAMP. The inc cAMP activates Protein Kinase A which then causes the physiological response observed in beta receptors. Beta 1 stimulation which are inc heart contractility, inc heart rate, inc lipolysis and inc renin release. Beta 2 stimulation results in inc heart contractility, inc heart rate, vasodilation of peripheral vessels, bronchodilation, inc lipolysis and inc glucagon release. Here's the funny thing....Renin release is associated with inc Angiotensin 2 levels which inc Aldosterone which is involved in Na+ and water retention.
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Originally Posted by jimmyinkedup
In your opinions then, do we use it (ben or ket) or is it bunk. If not, then what is the favored method/cycling? Thanks guys!
