3 Week Blitz cycle

[NoYokes]

having to increase the dose after the body gets used to taking it

[Phate]

having to increase the dose after the body gets used to taking it

the reason you have to take a higher dose to get the same results is because of a type of enzymes called cytochrome p450

MuscleScience wrote this about them

"Hey, MS, what's up with your body's recepters not responding to 'X' amount of test after a while? Does that apply to hrt? Can you tell me anything else about this?


Well its basically like this, when you take in a drug you take it at dose X over time the body builds up a tolerance to the drug because of a specific class of enzymes called cytochrome p450.(CYP) These enzymes are highly expressed in the liver and act to basically neutralize any foreign compound in the body. Due to continued exposure, over time CYP will be expressed in higher and higher amounts. Thus the liver is able to neutralize the drug faster. CYP is expressed in virtually all cell types to some extent its just that the liver is one place that it is very highly expressed.

This is one mechanism by which drug tolerance is developed. As CYP is expressed at higher and higher levels. A larger dose of a Drug is needed for the same therapeutic effect."

[NoYokes]

thats exactly what i wanted to know, thanks Phate!

[Phate]

thats exactly what i wanted to know, thanks Phate!

anytime bro, credit goes to musclescience though for the info