Tamoxifen Blocks HCG Induced Leydig Cell Desensitization

[LATS60]

Iv'e read this before, apart from having little bearing for the steroid user (because we dont use enough hCG to cause desensitization) the guy has totally misinterpreted the article he quoted.
Also it's seems this guy has fallen into the myth trap, exogenous hCG can work along side you're natural LH production, so to say this.
"Since we are trying to avoid this desensitization so when we quit the HCG our testes respond to our endogenous LH, it makes sense to always use nolvadex with HCG to at least help the problem, if not solve it completely".
Is wrong.
Of course it can be wise be take nolva with hCG because of the 300% rise in testosterone and the subsequent aromatisation to estrogen, especially if you are gyno prone.

[peachfuzz]

Lats, what if someone were to use high enough doses to desensitize Leydig cells? then aside from the assumption exogenous HCG can work alongside natural LH levels would this article hold some validity? I have seen alot of people on this board running HCG in much higher doses then are neccesary.

Also according to the article unless im reading it wrong it shows no differenct in T levels with with the concurrent administration of Tamoxifen.

Of course it can be wise be take nolva with hCG because of the 300% rise in testosterone and the subsequent aromatisation to estrogen, especially if you are gyno prone.

However, the association of Tx does not improve T serum levels, suggesting that E might not be the unique factor involved in the mechanisms for testicular desensitization.

[LATS60]

Lats, what if someone were to use high enough doses to desensitize Leydig cells? then aside from the assumption exogenous HCG can work alongside natural LH levels would this article hold some validity? I have seen alot of people on this board running HCG in much higher doses then are neccesary.

Also according to the article unless im reading it wrong it shows no differenct in T levels with with the concurrent administration of Tamoxifen.

Well it's not an assumption first off mate (thought you new me better LOL) it's a medical fact, taken from the many hCG and hypogonadic trials.
10000iu has been used in trials in one shot, this caused desensitization/leydig cell receptor saturation for 96 hrs.
Maybe i didn't make myself clear, i mean't that hCG alone gives a 300% rise in test and subsequent aromatisation to estrogen, so gyno prone individuals might want to run nolva with hCG anyway.

I don't give any credit to what the guy has assumed TBH, as i said he has misinterpreted the abstract, therefore his idea is flawed from the start, but the abstract in itself makes valid points.
IMO and from the research i have done adex would be a better choice especially if you start it a week before Hcg therapy, there are a few studies done on androgen priming with AI's before hCG use, results look promising.

[peachfuzz]

Well it's not an assumption first off mate (thought you new me better LOL) it's a medical fact, taken from the many hCG and hypogonadic trials.
10000iu has been used in trials in one shot, this caused desensitization/leydig cell receptor saturation for 96 hrs.
Maybe i didn't make myself clear, i mean't that hCG alone gives a 300% rise in test and subsequent aromatisation to estrogen, so gyno prone individuals might want to run nolva with hCG anyway.

I don't give any credit to what the guy has assumed TBH, as i said he has misinterpreted the abstract, therefore his idea is flawed from the start, but the abstract in itself makes valid points.
IMO and from the research i have done adex would be a better choice especially if you start it a week before Hcg therapy, there are a few studies done on androgen priming with AI's before hCG use, results look promising.

Ah now I get it. Thanks for clearing that up.