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  1. #1
    Join Date
    Oct 2005
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    Quote Originally Posted by Swifto View Post
    Intresting.

    PgR is synthsized in response to the ER in breast tissue and Tamox causes downregulation of the ER.

    I know these are breast cancer patients, so the results may not be able to compltely be transferred to the bodybuilder using AS. Breast cancer patients may show abnormal results, but I still think Tamox cen help with gyno from 19-Nor's. Although it will do nothing for PRL.
    Swifto I think the problem is that the studies dont really establish that progesterone activity is regulated by regulating the number of PgRs ....If so a good deductive connection would be made..




    Merc.

  2. #2
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    Oct 2004
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    Quote Originally Posted by Merc. View Post
    Swifto I think the problem is that the studies dont really establish that progesterone activity is regulated by regulating the number of PgRs ....If so a good deductive connection would be made..




    Merc.
    How else would PgR be regulated without regulating the PgR's?

    The fact is, Tamox is an antagonist in breast tissue (agonist in others tissues, yes) in healthy humans. So why wouldnt PgR follow suit with ER? In breast cancer this may be different.

    When I, you, take Tamox it downregulates the ER.

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