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Thread: Running AI on HCG

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  1. #1
    Join Date
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    Quote Originally Posted by cgb6810 View Post
    I thought the same thing, but a member recently pointed out that HCG does not increase estrogen through aromatase so an AI would not stop the increase in estrogen. Nolva will help though by blocking the estrogen receptor.

    Sorry, I would reference the thread but it was a while back.
    Actually it does by two pathways. Who ever posted that has no idea what their talking about.

    HCG can directly increase testicular estrogen. The testes produce around 10-15% of a males estrogen (healthy). HCG can directly stimulate this and an AI will not help. Tamoxifen will help block this testicular estrogen.

    The other pathway is HCG increasing endogenous testosterone by stimulating the leydig cells. It doesnt matter if your also using androgens, it will still increase endo. T. The increase in testosterone will then cause an increase in estrogen via aromotasation. Which an AI will help.

    HCG will also increase progesterone via degradation of testosterone.

    I always think an AI should be used at a low dose, unless your using HRT doses. Elevated estorgen can cause a host of problems, as can reduced estrogen (CNS function, labido, testosterone synthesis, GH and IGF production, bone density etc...) so keep it in NORMAL ranges.

  2. #2
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    Quote Originally Posted by Swifto View Post
    Actually it does by two pathways. Who ever posted that has no idea what their talking about.

    HCG can directly increase testicular estrogen. The testes produce around 10-15% of a males estrogen (healthy). HCG can directly stimulate this and an AI will not help. Tamoxifen will help block this testicular estrogen.

    The other pathway is HCG increasing endogenous testosterone by stimulating the leydig cells. It doesnt matter if your also using androgens, it will still increase endo. T. The increase in testosterone will then cause an increase in estrogen via aromotasation. Which an AI will help.

    HCG will also increase progesterone via degradation of testosterone.

    I always think an AI should be used at a low dose, unless your using HRT doses. Elevated estorgen can cause a host of problems, as can reduced estrogen (CNS function, labido, testosterone synthesis, GH and IGF production, bone density etc...) so keep it in NORMAL ranges.

    I was told that this action happened first, before test was increased. So during this time, an AI would not work. It wasn't until later that test would increase by stimulating the leydig cells.

    If this is true, then a Serm would be necessary if you were gyno prone. Would test increase enough from HCG alone that an AI would be needed?

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