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  1. #1
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    Quote Originally Posted by Xtralarg View Post
    Well ive just found the RB post and although it does make perfect sence it is not backed up by a study so I agree with what you say.

    How long have you been using HGH for now?
    I've been on this time since january and aim to stay on indefinitely.

    I first used GH back in '04 I think and since then have done runs of varying lengths and dosage protocols,

    5iu ed + 10iu PWO mon,wed,fri

    20iu PWO mon,wed,fri

    I am kinda of the belief that the timings aren't overly crucial and that its more the total number of iu's per week that dictates the results - but it's fun trying different methods!

  2. #2
    Quote Originally Posted by NotSmall View Post
    I've been on this time since january and aim to stay on indefinitely.

    I first used GH back in '04 I think and since then have done runs of varying lengths and dosage protocols,

    5iu ed + 10iu PWO mon,wed,fri

    20iu PWO mon,wed,fri

    I am kinda of the belief that the timings aren't overly crucial and that its more the total number of iu's per week that dictates the results - but it's fun trying different methods!
    Have you ever tried EOD?

    I have read books that state this is a good protocol because it more accurately replicates the human pusile frequency of gh.

    I have tried eod and had excellent results, but i have to say they were no better or worse than 5 on 2 off.....i guess like most other things its down to the individual and how they react.
    -XL

    jing jai

  3. #3
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    Quote Originally Posted by Xtralarg View Post
    Have you ever tried EOD?

    I have read books that state this is a good protocol because it more accurately replicates the human pusile frequency of gh.

    I have tried eod and had excellent results, but i have to say they were no better or worse than 5 on 2 off.....i guess like most other things its down to the individual and how they react.
    Nah, the closest to that I've done is the 20iu mon,wed,fri shot PWO with 12iu humalog which seemed very effective, but like we have both said - not necessarily any more or less effective than other dosing regimens.

    Max makes a very convincing scientific argument AGAINST the use of fast acting insulin PWO, however I have always thought that anecdotal eveidence from a decent amount of well respected peers is worth more than all the studies/science in the world (until someone actually funds a study entitled "The most effective administration of Growth Hormone for the purpose of bodybuilding" - don't hold your breath ) and I know LOADS of guys who have reported fantastic results from the GH + fast slin PWO combo.

    OK I have just made my own mind up, lol - during my 4 week blast I will continue with the 5iu GH at bedtime and 5iu GH upon waking and add an additional 10iu GH + 10iu fast slin PWO on mon,wed & fri.

  4. #4
    Quote Originally Posted by NotSmall View Post
    Nah, the closest to that I've done is the 20iu mon,wed,fri shot PWO with 12iu humalog which seemed very effective, but like we have both said - not necessarily any more or less effective than other dosing regimens.

    Max makes a very convincing scientific argument AGAINST the use of fast acting insulin PWO, however I have always thought that anecdotal eveidence from a decent amount of well respected peers is worth more than all the studies/science in the world (until someone actually funds a study entitled "The most effective administration of Growth Hormone for the purpose of bodybuilding" - don't hold your breath ) and I know LOADS of guys who have reported fantastic results from the GH + fast slin PWO combo.

    OK I have just made my own mind up, lol - during my 4 week blast I will continue with the 5iu GH at bedtime and 5iu GH upon waking and add an additional 10iu GH + 10iu fast slin PWO on mon,wed & fri.
    Is that why you decided to use the latnus insulin?

    I like the sound of your cycle, what sort of gains are you hoping for?
    -XL

    jing jai

  5. #5
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    Quote Originally Posted by Xtralarg View Post
    Is that why you decided to use the latnus insulin?

    I like the sound of your cycle, what sort of gains are you hoping for?
    Yeah Maxtiter is some kind of russian doctor - he blows my mind with some of the stuff he comes out with and he made a very strong case for the use of long acting slin, initially he favoured levemir/detemir (another long acting slin) but then he dug out some more research that seems to indicate that glargine slin i.e. lantus has 30 times the effect on IGF-1 receptors that levemir has and therefore should be ALOT more effective at building muscle.

    "It is still controversially discussed whether insulin triggers mitogenic effects through its own receptor, by interacting with IGF-1R or by activating insulin/IGF-1 hybrid receptors (Eckel, 2005).

    In the light of these discussions, the structural changes of the insulin molecule to create rapid- or long-acting insulin analogues become increasingly important. It is known that modifications in the B10 and B26-B30 region are able to change the affinity towards the IGF-1R (Slieker et al., 1997). This has been demonstrated for AspB10 insulin which is known for its strong tumourigenic action (Drejer, 1992). Studies investigating receptor binding properties of insulin analogues have shown that AspB10 insulin and insulin glargine have a 6 to 8-fold and insulin lispro a 1.5-fold higher affinity to the IGF-1R compared with regular insulin (Kurtzhals et al., 2000), while insulin aspart (Bornfeldt et al., 1991) and insulin glulisine (Ciaraldi et al., 2005; Rakatzi et al., 2003a) have a low affinity to the IGF-1R similar to regular insulin. For insulin detemir a 5-fold lower affinity to the IGF-1R has been found (Kurtzhals et al., 2000)."


    He advocates a working up to a dose of around 30ius of lantus with breakfast which will work all day and people do not seem to have any hypo problems because it does not lower blood sugar as quickly as the faster acting slins, it should just mean that you are soaking up every last bit of nutrition all day long!

    I just want to pack on some serious lean mass before cutting again - I couldn't put a number on it as I have never done a short high dose cycle like this before so I do not really know what to expect.

  6. #6
    Quote Originally Posted by NotSmall View Post
    Yeah Maxtiter on ukiron is some kind of russian doctor - he blows my mind with some of the stuff he comes out with and he made a very strong case for the use of long acting slin, initially he favoured levemir/detemir (another long acting slin) but then he dug out some more research that seems to indicate that glargine slin i.e. lantus has 30 times the effect on IGF-1 receptors that levemir has and therefore should be ALOT more effective at building muscle.

    "It is still controversially discussed whether insulin triggers mitogenic effects through its own receptor, by interacting with IGF-1R or by activating insulin/IGF-1 hybrid receptors (Eckel, 2005).

    In the light of these discussions, the structural changes of the insulin molecule to create rapid- or long-acting insulin analogues become increasingly important. It is known that modifications in the B10 and B26-B30 region are able to change the affinity towards the IGF-1R (Slieker et al., 1997). This has been demonstrated for AspB10 insulin which is known for its strong tumourigenic action (Drejer, 1992). Studies investigating receptor binding properties of insulin analogues have shown that AspB10 insulin and insulin glargine have a 6 to 8-fold and insulin lispro a 1.5-fold higher affinity to the IGF-1R compared with regular insulin (Kurtzhals et al., 2000), while insulin aspart (Bornfeldt et al., 1991) and insulin glulisine (Ciaraldi et al., 2005; Rakatzi et al., 2003a) have a low affinity to the IGF-1R similar to regular insulin. For insulin detemir a 5-fold lower affinity to the IGF-1R has been found (Kurtzhals et al., 2000)."


    He advocates a working up to a dose of around 30ius of lantus with breakfast which will work all day and people do not seem to have any hypo problems because it does not lower blood sugar as quickly as the faster acting slins, it should just mean that you are soaking up every last bit of nutrition all day long!

    I just want to pack on some serious lean mass before cutting again - I couldn't put a number on it as I have never done a short high dose cycle like this before so I do not really know what to expect.
    Well if thats true and the effects of a long acting slin are such then it is a no brainer! I will keep reading and looking to see what people report!

    I reckon you should be adding at lthe very least 1-1.5 kilos ed with a cycle like that.......
    -XL

    jing jai

  7. #7
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    Quote Originally Posted by Xtralarg View Post
    Well if thats true and the effects of a long acting slin are such then it is a no brainer! I will keep reading and looking to see what people report!

    I reckon you should be adding at lthe very least 1-1.5 kilos ed with a cycle like that.......
    Yup - I'm going to drop my prop dose right down in the 2 weeks before I start then eat like FUCK, take digestive enzymes and R-ALA before every meal to make sure I absorb every last calorie and obviously will be running thyroid hormones to keep my protein turn over rate at full tilt - really quite excited about it - should be starting on the 5th July!

  8. #8
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    Quote Originally Posted by NotSmall View Post
    Yeah Maxtiter is some kind of russian doctor - he blows my mind with some of the stuff he comes out with and he made a very strong case for the use of long acting slin, initially he favoured levemir/detemir (another long acting slin) but then he dug out some more research that seems to indicate that glargine slin i.e. lantus has 30 times the effect on IGF-1 receptors that levemir has and therefore should be ALOT more effective at building muscle.

    "It is still controversially discussed whether insulin triggers mitogenic effects through its own receptor, by interacting with IGF-1R or by activating insulin/IGF-1 hybrid receptors (Eckel, 2005).

    In the light of these discussions, the structural changes of the insulin molecule to create rapid- or long-acting insulin analogues become increasingly important. It is known that modifications in the B10 and B26-B30 region are able to change the affinity towards the IGF-1R (Slieker et al., 1997). This has been demonstrated for AspB10 insulin which is known for its strong tumourigenic action (Drejer, 1992). Studies investigating receptor binding properties of insulin analogues have shown that AspB10 insulin and insulin glargine have a 6 to 8-fold and insulin lispro a 1.5-fold higher affinity to the IGF-1R compared with regular insulin (Kurtzhals et al., 2000), while insulin aspart (Bornfeldt et al., 1991) and insulin glulisine (Ciaraldi et al., 2005; Rakatzi et al., 2003a) have a low affinity to the IGF-1R similar to regular insulin. For insulin detemir a 5-fold lower affinity to the IGF-1R has been found (Kurtzhals et al., 2000)."

    He advocates a working up to a dose of around 30ius of lantus with breakfast which will work all day and people do not seem to have any hypo problems because it does not lower blood sugar as quickly as the faster acting slins, it should just mean that you are soaking up every last bit of nutrition all day long!

    I just want to pack on some serious lean mass before cutting again - I couldn't put a number on it as I have never done a short high dose cycle like this before so I do not really know what to expect.

    DUDE..... keep me informed on your progress. One of my good friends is running 5iu's hgh, no less than 750 test and throws tren and dbol in there on and off..... also uses 10iu's humalin-R PWO with 100mcg's IGF-1..... this kid is a beast. I always remember reading humalog was the best slin to use because it's out so fast but you've got me curious.

    I'm not ready to take the slin plunge yet but I'm considering it for my winter run.....

    I also may be upping my gh to 10iu's/day while I run my test/tren/mast this summer.

    ~Haz~

  9. #9
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    Quote Originally Posted by Hazard View Post
    DUDE..... keep me informed on your progress. One of my good friends is running 5iu's hgh, no less than 750 test and throws tren and dbol in there on and off..... also uses 10iu's humalin-R PWO with 100mcg's IGF-1..... this kid is a beast. I always remember reading humalog was the best slin to use because it's out so fast but you've got me curious.

    I'm not ready to take the slin plunge yet but I'm considering it for my winter run.....

    I also may be upping my gh to 10iu's/day while I run my test/tren/mast this summer.

    ~Haz~
    This is what we all thought because we read it and it seems to make logical sense, what Maxititer says is that because the effect of humalog is SO quick it does not have time to spread throughout the body but instead tends to cause the vast majority of blood sugar to to pushed into the liver rather than skeletal muscle.

    I'll be running my cycle with long acting slin in july so I will be able to report my actual experience as opposed to just quoting my mate Max lol

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