
Originally Posted by
PPC
Some guys do not do well on oral dhea or pregnenolone. DHEA in oral form can raise estradiol and estrone levels in some. Oral pregnenolone can have an anti anxiety effect so much so that is becomes a Klonopin type med in the body for some people. Seems transdermal forms do not pose these problems.
High enough doses of pregnenolone may backfill dhea that is too low and that maybe a two for one. 'May' is the operative word here, trial and testing will show what your body does with these hormones.
There are OTC pregnenolone and dhea creams available but usually at low doses. Compounding pharmacies can put together higher strength creams which may be more desirable so one is not having to slap on handfuls of cream.