Clenbuterol makeing me tired???

[jtuner77]

The best bet by far is to do 2 weeks on / 2 off. Using ketotifen , IMO , is not prudent . Look at the side effcts of ketotifen (ie: marked drowsiness , weightgain). They are 100% contradictiry to our goal. Also continuous or prolongded stimulation of beta receptors is not prudent for several reasons- regardless whether or not downregulation has been minimized.. Im not sure if the 2 week on / 2 off started as a result of real life effectiveness or not (which it is very effective btw) - BUT it is 100% clinically supported as substances like allbuterol require that the amount of time between use of mao inhbitors - is 2 weeks - because that is when the body has no effect whatsoevcer of the b2 agonist or conversely the maoi usage. Im not quite sure what the hell up downregulation is , im not sure why you would increase dosage and increase dangers , and im not sure anyone who knew what they were doing would want to stimulate b2 recpetors for an extended period of time.
I do not doubt the intent of those posting in this thread is to help. That being said there is some serious misinterpreted cut and paste, contradictory, and overall inaccurate information in this thread - this post is my opinion - however at least it is based on fact , is the safest , most prudent, and also very effective method.
To each his own.

Please tell me how 2 weeks off allows or helps up downregulation? What study has proven this theory? Your personal experience?

I guess to each his own. I speak mostly of what I have dealt with first hand as well as what have been sited by other users that have first hand experience. None the less this thread is getting off topic to what the OP was asking. I hope this gave you some insight into your situation OP.

[jimmyinkedup]

Please tell me how 2 weeks off allows or helps up downregulation? What study has proven this theory? Your personal experience?

There are no studies showing what helps with "up downregulation". nothing helps with "up downregulation."
BECAUSE THERE IS NOTHING CALLED "UP DOWNREGULATION." Thats what someone who reads posts on lousy sites like bb.com, or a few paragraphs on wikipedia that they misinterpret , they they try to post like they have vast experince on the topic, says when they are referring to upregulation.
Its upregulation or downregulation.
Look i know you are trying to be helpful but do you know the possible effects of long term beta receptor stimulation ? Its dramatically reduced endurance and enlargement of the heart. We can all learn from one another , but when someone posts info acting like they have all this knowledge regarding it and give out not only technically inaccurate but also imprudent advice with potential advese health effects and recommend it to others - i get a little upset. You incorrectly post ephedrines moa , you call upregulation "up downregulation", your posts contradict each other , and you are acting like you have vast knowledge and experince in this area and can help. Id say you have much to learn based on the above and your imprudent advice. Now look Im not trying to bash you - I just hope you understand thsast the advice you give here may be implemented by people - to give advice on things you truly do not understand with suibstances like the ones we discuss can be dangerous - please keep that in mind. Now I dont wish to get into a pissing contest and as far as Im concerned this interaction is over and in the past with no adverse feelings either way - lets move on.
So this is how 2wo/2wo works:
2weeks on / 2 weeks off minimizes the extent of downregulation due to limited ingestion timeframe and thus limited (short duration)effect on beta receptor. Then 2 weeks off allows upregulation because the beta recpetor is not being exogenously stimulated.
Combine that with real world effectiveness and you have a winner.

[jimmyinkedup]

If you read my earlier posts you would see where i stated the 2on/2off method eliminates the need for increasing dosages to maintain effectiveness (thus further proving it is working at preventing downregulation).....this allows for very effective results using low doses of these substances. Not sure how this could not be considered the most prudent course of action but to each his own.
We can both be done - even agree to disagree - im fine with that.