Ever wonder where the "high" went after initially starting TRT?

[JD250]

Yep^^^ I know many guys including myself have reported feeling a big difference within the first week or so which doesn't line up with what we know about the effects of testosterone but now we know it's the dopamine that's acting that quickly. Good info.

[steroid.com 1]

Yep^^^ I know many guys including myself have reported feeling a big difference within the first week or so which doesn't line up with what we know about the effects of testosterone but now we know it's the dopamine that's acting that quickly. Good info.

Correct JD; that's part of his point.

There are other jems in this paper if you haven't caught them; but it's this statement that's worth every penny in reading and understanding:

So what happens when testosterone is replaced?

There is a reversal of some of the initial signaling problems.

Because there is a larger number of dopamine receptors from the dopamine signaling deficit caused by the loss of testosterone , there is dopamine supersensitivity to the surge of dopamine signaling that accompanies the increase in testosterone with repla***ent. This can cause a high - with heightened sex drive, alertness. and an elevated mood.

Testosterone would also free up thyroid hormone by reducing thyroid binding globulin, reversing estrogen's effects, improving function from this angle. This would improve energy

Testosterone would then reduce excessive norepinephrine signaling, which as it comes more in normal physiologic strength, helps dopamine in providing a higher level of libido, sex drive, and an emotional high.

The testosterone to estrogen ratio would improve, reducing effects of excess estrogen. Insulin signaling is reduced. The body becomes less in an inflammatory state.

The person feels better, if not feels a high from the initial treatment with testosterone .

WONDERFUL!