AI's and Joints

[frigger]

Hello everyone. I've been on TRT (compounded cream) for three weeks now. I was prescribed Anastrozole along with the TRT, and was supposed to take .5mg EOD. Not only did this drive my E2 down dangerously low (<3), but it also did a number on my joints. Lots of cracking and popping and generally feeling dry and stiff. I've experimented with the dose and frequency, and found the smallest amount i can take to keep high E symptoms at bay is 0.125 mg EOD or E3D. Though this still drives my E2 quite low (7), and unfortunately, this still leaves me with dry and cracking joints (though no pain yet). It seems I may be a hyper-responder to AIs.

Does Aromasin have less of an effect on joints? What about alternatives like Indolplex, Zinc, or others? Or does low E2 just simply mean dry joints?

Thanks kindly

[bass]

you totally crashed your e2, it will take a long time to get back to normal. my suggestion is to come off completely then do BW 4-6 weeks later then make adjustments. that was way too much AI to begin with especially being on gel. i did the same thing so i know how you feel.

[steroid.com 1]

Most men on a cream/gel do not even require an AI as there are very little shifts in serum levels.

.5 mg EOD on a cream (you didn't state dosage) appears extreme to me and why you have neg sides of low E2.

You should present no neg sides if your AI is dosed correctly.

I would come off it completely and get tested in 6 weeks and start a baseline than go from there.

Is your protocol Doctor supervised? If so, what did they say?

[flatscat]

Please explain this ^^^^

Sounds like you are suggesting that conversion only or mainly happens during spikes.

Thanks

[kelkel]

Frigger you may want to get some nolvadex on had to prevent sides from your forthcoming E rebounding. It will allow your E to rise and block receptors in your breast.

[Vettester]

Estro rebound ... Not gonna be fun.

[frigger]

Kelkel, thanks for the tip. What does do you recommend and how frequent? Consider I seem to be sensitive to these things.

Frigger you may want to get some nolvadex on had to prevent sides from your forthcoming E rebounding. It will allow your E to rise and block receptors in your breast.

[frigger]

vetteman.. i'm new to TRT.. what can I expect? Will i soon get a big surge of estro? do you also recommend some nolva?

Estro rebound ... Not gonna be fun.

[kelkel]

Frigger a lot of us have been where you are and it seems more and more prevelant lately as everyone is terrified of gyno and starts high instead of low with AI's. I would recommend 20mg nolva daily and re-test in a month. You will spike back up and this will protect you during that time frame. After testing you should be able to wean off/stop the nolva and go without anything for a period of time while your E continues to rise at a much slower rate. I'd do monthly testing for a while after that if possible. You could be hyper-sensitive to AI's but you could also just be a low converter to E. I myself may very well be a low converter ...

Vette will tell you the same thing.....

[frigger]

Frigger a lot of us have been where you are and it seems more and more prevelant lately as everyone is terrified of gyno and starts high instead of low with AI's. I would recommend 20mg nolva daily and re-test in a month. You will spike back up and this will protect you during that time frame. After testing you should be able to wean off/stop the nolva and go without anything for a period of time while your E continues to rise and a much slower rate. I'd do monthly testing for a while after that if possible. You could be hyper-sensitive to AI's but you could also just be a low converter to E. I myself may very well be a low converter myself.

Vette will tell you the same thing.....

Thanks kindly kelkel.
If yesterday was my last dose of Anastrozole, when do you think i should start on the nolva? should i let me E2 rise a bit first to get em out of the low e danger zone?

[Vettester]

Concur completely with Kelkel.

The actual rebound time is different with everyone. Just keep your thread alive as things progress, we'll be here to see you through. You're not going to have a lot of conversion going on with the cream (at least I don't think you will), so it may take a little more time. The body will work to find homeostasis, just be patient.

[Vettester]

Keep the Nolva ready until you feel the receptors start to act up. This will be the indicator that it's in motion.

[flatscat]

Please explain this ^^^^

Sounds like you are suggesting that conversion only or mainly happens during spikes.

Thanks

This was left unexplained

[bass]

This was left unexplained

i've read allot of GD's posts and from what i understand he believes you get more conversion when levels spike drastically, thats doesn't mean if your steady level is at 1200 you won't convert, i think this theory works only with low doses TRT like 100-120 mgs per week. anything higher most likely will require some AI.

[flatscat]

Well, there you have it.