Why not low dose clomiphene instead of HCG on TRT?

[go2failure]

Gentlemen,

I appreciate your efforts, but I still don`t follow you. I`m usually slow to pick up things, so please bear with me.

I am not talking of PCT or attempting to restart the HPT axis and I`m well aware that HCG shut downs LH production.

I`m talking about using clomiphene instead of HCG while using exogenous testosterone on TRT.

From Dr. Crisler's HCG update:

The P450 Side Chain Cleavage enzyme, which converts CHOL into pregnenolone at the initiation of all three metabolic pathways CHOL serves as precursor (the sex hormones, glucocorticoids and mineralcorticoids), is actively stimulated, or depressed, by LH concentrations. It is intuitively consistent that during conditions of lowered testosterone levels, commensurate increases in LH production would serve to stimulate this conversion from CHOL into these pathways, thereby feeding more raw material for increased hormone production. And vice versa. Thus the addition of HCG (which also stimulates the P450scc enzyme) helps restore a more natural balance of the hormones within this pathway in patients who are entirely, or even partially, HPTA-suppressed.


Dr. Crisler and the other posters are trying to say that HCG is way more beneficial to the TRT protocol than without. Clomid binds to estrogen receptors to work and in some people gives the feeling of estrogen dominance (ED, bloating, fatigue, hot flashes, etc). It also has been known to cause temporary/permanent vision problems starting at low doses. Like the previous poster alluded, at some point Clomid completes the HPTA loop from the stimulation it provides and it begins to negate its own production.