I totally agree with you gixx for most people. I have a friend that at 500 mg/week his E2 is right in the middle of normal. I also have a friend that needs an AI on his TRT dose of 200 mg/week. These guys are not the norm. But to be totally sure of what and how much of an AI you need to control E2 is to have bw. And there's no reason not to have it done because the private labs are very reasonable.