Quote Originally Posted by MickeyKnox View Post
i agree with most of what you posted but nolva does not prevent the aromatization, it acts as an estrogen antagonist. clomid on the other hand deactivates most of the increased estrogen and prevents it from attaching to the receptors.
That's wrong.

Where are you getting this information?

Clomid is a SERM (Selective Estrogen Receptor Modulator), not an AI (Aromatase Inhibitor). You are confusing Clomid with AIs. Yes, Clomid prevents estrogen from attaching to its receptors. But, how does Clomid 'deactivate' increased estrogen? This is not possible at all. Please provide me with some sources to back up this statement.

SERMs block, not lower estrogen, nor do they 'deactivate' serum Estrogen...

I cannot believe the amount of misunderstanding around here concerning this! Clomid and Nolvadex are mixed antagonists/agonists of the ER (Estrogen Receptor) in all kinds of different tissues in the body. Clomid is more of an agonist than Nolvadex is in certain tissues, but not breast tissue where Nolvadex is more effective. It's known that Clomid acts as an agonist in certain parts of the brain that control emotion, hence the emotiuonal sides experienced.

Both are antagonists in breast tissue and the hypothaalamus (hence the serum Testosterone increase) but its postulated Tamoxifen is more an an antagonist at the pituitary and Clomid an agonist. Both seem to be agonists in the liver and other selective tissues.

If you wish to lower estrogen, you'de need to invest in an AI (Aromotase Inhibitor). They inhibit the enzyme aromotase which is responsible for converting testosterone to estrogen.

You need to do more research on SERMs Clomid and Nolvadex, and you need to do more research on the difference between SERMs and AIs.