var is some pretty forgiving shit. most important is the dose. slightly important (or not at all?) is if you split it up to maintain blood serum levels.
I'd almost say splitting it is a push. really don't notice any difference.
yeah, a lower dose may be in your blood stream more often
but the other way, you have a much higher dose for 9 hours of the day.
it all pretty much averages out if you ask me.
no, i have no data to support. just personal experience.