No. Clen is a beta receptor agonist. It stimulates the sympathetic nervouse system in a similair way to epinephrine. Propranolol is a beta receptor antagonist. It blocks the receptor so sympathamomemics like epinephrine, clen, and albuterol can't stimulate the receptor. In fact, taking propranolol alongside clen would actually block clen from illiciting it's effects.