AIs and Lipid Values???

[jimmyinkedup]

I just posted on this in the trt forum. I think the benefit to exemestane as far as lipid values and igf are direc tly related to estrogen (no shock there). While often it is stated that exemestane is "stronger" than anastrozole ..the fact is , as shown in this study ( http://jcem.endojournals.org/content/88/12/5951.full ) even at doses of 50mg/day , while e2 was drastically reduced..it was still at the low end of normal clinical range. My point being I think its easier to "crush" e2 levels with anastrozole than with exemestane. I am pretty thoroughly convinced all the igf / lipid effects of ai's are related to their effect as far as mediating e2. E2 play a critical role in lipid values and also a key role in igf production in the liver. What I find more interesting is that serm like tamoxifen actually decreases igf...but thats another thread/topic.

[warmouth]

I just posted on this in the trt forum. I think the benefit to exemestane as far as lipid values and igf are direc tly related to estrogen (no shock there). While often it is stated that exemestane is "stronger" than anastrozole ..the fact is , as shown in this study ( http://jcem.endojournals.org/content/88/12/5951.full ) even at doses of 50mg/day , while e2 was drastically reduced..it was still at the low end of normal clinical range. My point being I think its easier to "crush" e2 levels with anastrozole than with exemestane. I am pretty thoroughly convinced all the igf / lipid effects of ai's are related to their effect as far as mediating e2. E2 play a critical role in lipid values and also a key role in igf production in the liver. What I find more interesting is that serm like tamoxifen actually decreases igf...but thats another thread/topic.

Somy BW results could have had something to do with liquidex? And are you saying that "crushing" E2 helps lipids or harms them? Is the correlation between estrogen and lipids that estrogen induces raised levels or reduces? The artice is amazing, I am just having a hard time taking it all in. I have read it several times.

[jimmyinkedup]

Somy BW results could have had something to do with liquidex? And are you saying that "crushing" E2 helps lipids or harms them? Is the correlation between estrogen and lipids that estrogen induces raised levels or reduces? The artice is amazing, I am just having a hard time taking it all in. I have read it several times.

Estrgoen improves lipid profile. "Crushing" e2 has an adverse effect on lipids.
Progesterone has an adverse effect on lipids - so , for example a cycle with a progestin like say deca or tren , can adversely effect your lipid profile.