Dumbass q - how do you put together a cycle?

[Bonaparte]

Yes. I think I worded it awfully wrong. The 5AR activity was meant as these compounds strongly tend to have an affinity for type 1 5AR and type 2 5AR. Which is why you notice, these compounds right under the skin and that is why they exhibit their effects so strongly there. I don't know how to explain exactly how or why they are attracted to the 5AR enzymes so strongly but they seem to have an attraction to those regions where 5AR enzymes are. OR I could just be confused to the expression these drugs have after AR binding, but I don't think that is the case. They really seem to stay active in the skin, this is why these drugs increase sebaceous gland excretion so much... It seems unlikely that their expression would produce that effect if they weren't attracted to 5AR regions..

DHN enhances the "androgenicity" sure.. But it has a much lower AR affinity..

And here is where all the confusion stems from. DHT-derivatives (or 5a-reduced compounds) seem more "active under the skin" because they share the anti-estrogenic properties of DHT. So they reduces estrogen levels, which reduces sub-Q water retention. They also encourage lipolysis. And the reason for the acne is because they bind tightly to the AR and are androgenic (if we're talking about the more androgenic ones, like masteron), and increased sebum production is an androgenic side effect. They have NO affinity for the 5a-r enzyme and CANNOT interact with it.

[Sworder]

And here is where all the confusion stems from. DHT-derivatives (or 5a-reduced compounds) seem more "active under the skin" because they share the anti-estrogenic properties of DHT. So they reduces estrogen levels, which reduces sub-Q water retention. They also encourage lipolysis. And the reason for the acne is because they bind tightly to the AR and are androgenic (if we're talking about the more androgenic ones, like masteron), and increased sebum production is an androgenic side effect. They have NO affinity for the 5a-r enzyme and CANNOT interact with it.

I was thinking they did some how, as when a 5AR inhibitor is used; the androgenic effects seem to diminish in the skin and scalp. Not saying they are binding, but attracted lmao...

[Bonaparte]

I was thinking they did some how, as when a 5AR inhibitor is used; the androgenic effects seem to diminish in the skin and scalp. Not saying they are binding, but attracted lmao...

Only if you're using test as well. Otherwise, 5a-r inhibitors have no effect.