Side effects, and the lack of research on humans as far as permantent heart damage. The stuff doesnt have the same "feeling" as most stimulants(coffee, ephed, caffine, amphets, etc). You cant "feel" it at all. It makes your heart POUND and I my heart beat has woke my wife up at night. I can see my heart beat through my chest and stomach. It is thought to permanantly alter the walls of the left ventricle of the heart as well as hardening of the artieries(several threads on this). I feel safer running ephederine, as it is used for humans, not chickens or pigs like clen. Everyone is different, and many people use clen. For me, the risk outweights the reward, especially when you can get the same results by diet and cardio. Sure, it will take longer, but you are improving your heart and not damaging it. If I had the choice, I would try GW, as Tdogg said. But as far as anything else, ECA all the way.
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