Let's talk about Depression

[HRTstudent]

Androgen supplementation always decreases SHBG, not the other way around. So I don't know where you picking that up, it is pretty common knowledge that the introduction of androgens reduce SHBG.

Trust me when I say there is no way to increase it, I know a few guys that have been on the boards for years, and they low SHBG and have no way to fix it.

If your SHBG is low you have no business on an Aromatase inhibitor.

How can you make a blanket statement like that? (I genuinely want to know and I'm not just inciting you.)

Myself as an example, I always had low SHBG and even on a mild T dose I ran into high E2 and gynecomastia. I opted for an AI rather than coming off TRT.

[THE-DET-OAK]

How can you make a blanket statement like that? (I genuinely want to know and I'm not just inciting you.)

Myself as an example, I always had low SHBG and even on a mild T dose I ran into high E2 and gynecomastia. I opted for an AI rather than coming off TRT.

You had a blood test, and your E2 was really high, and your SHBG was low?

[HRTstudent]

You had a blood test, and your E2 was really high, and your SHBG was low?

I've had lots. Never had SHBG over 20. E2 has been anywhere from almost nothing to around 50 (<29 range).

Before I got on an AI my E2 was going up until I had to start an AI after taking 3 pumps androgel a day.

If that were really the case then your dose was too high, or you have sleep apnea, or diabetes most likely. Either way all those things would need to be considered.

and yes I would lower my dose or switch to cream before adding an AI if my SHBG was below 10, your asking for some serious negative health risks by adding the AI, it will simply further suppress SHBG, and I can not stress enough how that is bad for you

Don't have diabetes and my blood sugar tests were all really good.

Dose being too high is interesting because it did not take too much for me to get gyno even on androgel 4 pumps or less.

My SHBG has never been below 10 according to bloods, but thereabouts.

What is so bad about low SHBG? Do you mean low-normal or below-normal only?