Adex dosage??

[MuscleInk]

300 would be a bit exaggerated....since I'm sure there would be symptoms that you could feel or see. My main point it just you don't know how the cycle is going to affect you, why throw another chem in the mix if it's not needed? Especially when people are afraid of results on bloodwork if estrogen comes back high....and they feel great. It should be high if your on a cycle with no AI. If you aren't gyno prone, aren't bloated like crazy, mood and libido is good....don't go adding in adex just because some people on a forum tell you to. Use the medication for problems only if needed. But there could be the guy who can run 1-2grams of test and with no AI and the guy who needs AI on 500mg.....it's trial and error, with bloodwork as a guide. But don't just follow the numbers.

It's all different for each person. Myself, I find even on TRT that E2 at bit less then double the 'ideal range' is where my 'ideal' numbers are. If I was just listening to others and going by blood results I'd still feel like shit with no libido.

Allaaro,

I hear this all too often that it not only concerns me but shows me that people really do NOT spend enough time understanding the effects of manipulating hormones with steroids. While I will agree that taking too much of an AI can have undesirable and potentially harmful effects, there are far greater concerns than gyno or bloating with elevated E2. With increasing estrogen, hypertension, hypercholesterolemia, heart attack, deep vein thrombosis, and strokes become a significant risk. Does this mean every person with high estrogen levels is at risk for these? No, but without a complete medical hx (which we never have with members here) its simply not possible to know who is at risk and how significant that risk may be. Moreover, strokes, heart attacks, and DVTs are often asymptomatic, yet deadly.

It would be foolish IMO for someone to manipulate their natural hormones and assume they don't need an AI unless they are symptomatic. It creates an unnecessary risk. I will also agree the the optimal level of E2 will vary from person to person but I believe it is careless to assume one can avoid an AI unless there are clinical presentations of high estrogen. There is simply no way of knowing, a priori, what the optimal level of E2 would be for each person.

Routine BW would be create for keeping E2 in check, but the reality is, most people don't have routine BW due to cost, insurance, access, convenience, or any other factor.

[>Good Luck<]

Allaaro,

I hear this all too often that it not only concerns me but shows me that people really do NOT spend enough time understanding the effects of manipulating hormones with steroids. While I will agree that taking too much of an AI can have undesirable and potentially harmful effects, there are far greater concerns than gyno or bloating with elevated E2. With increasing estrogen, hypertension, hypercholesterolemia, heart attack, deep vein thrombosis, and strokes become a significant risk. Does this mean every person with high estrogen levels is at risk for these? No, but without a complete medical hx (which we never have with members here) its simply not possible to know who is at risk and how significant that risk may be. Moreover, strokes, heart attacks, and DVTs are often asymptomatic, yet deadly.

It would be foolish IMO for someone to manipulate their natural hormones and assume they don't need an AI unless they are symptomatic. It creates an unnecessary risk. I will also agree the the optimal level of E2 will vary from person to person but I believe it is careless to assume one can avoid an AI unless there are clinical presentations of high estrogen. There is simply no way of knowing, a priori, what the optimal level of E2 would be for each person.

Routine BW would be create for keeping E2 in check, but the reality is, most people don't have routine BW due to cost, insurance, access, convenience, or any other factor.

That's a wicked response bro. I was reading this thread because I feel like my AI made me feel like crap last cycle. I was feeling like I should skip it this upcoming cycle but now after reading your post it make it a bit more clear as to why it is necessary.

Sorry to jack the thread but I feel this question can help anyone else trying to understand the use of AI and e2 management... If I was taking liquidex at .25eod and felt very sluggish on cycle and often couldn't stay awake, had some moodiness and got sick randomly, could my e2 have been too low? Could I try .25mg e3d to see how I react to that? Cuz for me the only benefit of the AI that I noticed was less acne...which was great

[MuscleInk]

That's a wicked response bro. I was reading this thread because I feel like my AI made me feel like crap last cycle. I was feeling like I should skip it this upcoming cycle but now after reading your post it make it a bit more clear as to why it is necessary.

Sorry to jack the thread but I feel this question can help anyone else trying to understand the use of AI and e2 management... If I was taking liquidex at .25eod and felt very sluggish on cycle and often couldn't stay awake, had some moodiness and got sick randomly, could my e2 have been too low? Could I try .25mg e3d to see how I react to that? Cuz for me the only benefit of the AI that I noticed was less acne...which was great

AI dosing is a bit tricky. Two people can take the same dose and have very different outcomes. Another problem is that some symptoms of low E are also the same with high E (libido, ED, lethargy, joint/muscle pain, etc.). BW is more definitive for checking E2, but its not practical for most people to check it regularly. I always recommend the lowest possible dose of Adex to start: .25 EOD. Adex has a half life of nearly 48 hours, so extending your dose to E3D should pose a significant concern.

Another option could be aromasin. One benefit of exemestane is that is has less of an effect on lipids than Adex which is a huge benefit for people prone to hypercholesterolemia an hypertension. The disadvantage of stane/aromasin is that its a "suicide inhibitor" and has more permanent effect on receptor coupling.

Try the Adex at 0.25 E3D and see how you feel. Keep me informed. I'd be interested in your feedback.

[>Good Luck<]

AI dosing is a bit tricky. Two people can take the same dose and have very different outcomes. Another problem is that some symptoms of low E are also the same with high E (libido, ED, lethargy, joint/muscle pain, etc.). BW is more definitive for checking E2, but its not practical for most people to check it regularly. I always recommend the lowest possible dose of Adex to start: .25 EOD. Adex has a half life of nearly 48 hours, so extending your dose to E3D should pose a significant concern.

Another option could be aromasin. One benefit of exemestane is that is has less of an effect on lipids than Adex which is a huge benefit for people prone to hypercholesterolemia an hypertension. The disadvantage of stane/aromasin is that its a "suicide inhibitor" and has more permanent effect on receptor coupling.

Try the Adex at 0.25 E3D and see how you feel. Keep me informed. I'd be interested in your feedback.

One last thing... What the f--- is "suicide inhibitor"

[MuscleInk]

One last thing... What the f--- is "suicide inhibitor"

Well....without complicating the answer with reference to covalent bonds and such, the short answer is that aromasin permanently binds to aromatase enzymes, preventing them from converting androgen into estrogen.

[MickeyKnox]

Allaaro,

I hear this all too often that it not only concerns me but shows me that people really do NOT spend enough time understanding the effects of manipulating hormones with steroids. While I will agree that taking too much of an AI can have undesirable and potentially harmful effects, there are far greater concerns than gyno or bloating with elevated E2. With increasing estrogen, hypertension, hypercholesterolemia, heart attack, deep vein thrombosis, and strokes become a significant risk. Does this mean every person with high estrogen levels is at risk for these? No, but without a complete medical hx (which we never have with members here) its simply not possible to know who is at risk and how significant that risk may be. Moreover, strokes, heart attacks, and DVTs are often asymptomatic, yet deadly.

It would be foolish IMO for someone to manipulate their natural hormones and assume they don't need an AI unless they are symptomatic. It creates an unnecessary risk. I will also agree the the optimal level of E2 will vary from person to person but I believe it is careless to assume one can avoid an AI unless there are clinical presentations of high estrogen. There is simply no way of knowing, a priori, what the optimal level of E2 would be for each person.

Routine BW would be create for keeping E2 in check, but the reality is, most people don't have routine BW due to cost, insurance, access, convenience, or any other factor.

I always enjoy your responses, particularly the elegant way in which you present your medically backed up opinions.

[Fllifter]

Awesome response MI , I have some buddies that I try and get to run an Ai but refuse to (because they don't get gyno so they think there's no need) I'm just gonna save your response and show them .

[MuscleInk]

Awesome response MI , I have some buddies that I try and get to run an Ai but refuse to (because they don't get gyno so they think there's no need) I'm just gonna save your response and show them .

Happy to help.