Nolvadex best T-booster of the SERMS
You’ve just taken a course of steroids and are looking for something to normalise your testosterone level. You can’t make up your mind between good old nolvadex, alias tamoxifen, and its cousins raloxifene and toremifene. Greek researchers have published the results of a study in Fertility & Sterility which suggests that tamoxifen is the best choice.
Tamoxifen, raloxifene and toremifene are SERMs: they attach themselves to the receptor for estradiol but don’t start up the processes that usually follow after estradiol has attached itself to its receptor. That’s why doctors use SERMS against tumours whose growth is stimulated by female hormones.
Chemical athletes use SERMs because they raise the testosterone level. One of the ways that the body monitors its own production of sex hormones is by keeping an eye on the concentration of estradiol in the blood. If it gets too high then sex hormone production is reduced – including the production of testosterone. Because the control mechanisms make use of estradiol receptors, SERMs crank up testosterone production. That’s why chemical athletes use substances like tamoxifen after taking a course of steroids.
The Greek researchers did a trial with just under three hundred infertile men, whose sperm count was low and most of whom had low levels of testosterone production. The researchers gave the men either 20 mg tamoxifen, 60 mg toremifene or 60 mg raloxifene daily for three months. The table below shows what happened to the men’s LH, FSH and testosterone levels.
Raloxifene has little effect on the testosterone level, so it’s not an interesting candidate for a Post Cycle Therapy supplement. Toremifene is somewhat better, but doesn’t perform as well as tamoxifen, and it loses its maximum effect after two months as well.
To complete the story we’ve added the table below, which shows the effect of the three on sperm cells. Once again, raloxifene performs less well than tamoxifen and toremifene.
The researchers suspect that the two more effective SERMs not only work through the body’s hormonal thermostat, thereby inducing the pituitary gland to make more messenger hormones [which in turn get the testes to produce more testosterone]. They think that tamoxifen and toremifene also have a direct effect on the testosterone producing cells.
Source: Fertil Steril. 2009 Apr;91(4 Suppl):1427-30.
ergo-log
The article below is particularly interesting because it shows how Nolvadex is still effective even when taken simultaneously with Testosterone.
Testicle size worries? Try a course of Nolvadex + Andriol
Taking steroids by definition reduces your body’s own testosterone production, underground handbooks will tell you. Well, not necessarily. In the 1990s Greek endocrinologists at the Elena Venizelou Hospital published the results of a study in which they had given men light doses that increased the body’s own testosterone production.
In an article published in Fertility & Sterility in 1997, the Greeks describe an experiment they did with eighty men who had low sperm counts. Some of them were given fake medicine – the placebo group. Another group were given 10 mg tamoxifen, the active ingredient in Nolvadex, twice a day. The third group were given three capsules a day containing 40 mg of testosterone undecanoate, the active ingredient in Andriol. [The structures of both these are shown above.] The last group took both Nolvadex and testosterone-undecanoate. The researchers measured the hormone levels in the men’s blood and their sperm quality after three and six months.
The researchers reported that there was quite a difference in the values for testosterone and for FSH – a messenger hormone that triggers the production of testosterone in the testes. But from the patchy information they give, we’ve managed to put together the table below. The picture is clear, but not all trends are statistically significant. N= Nolvadex; N+A = Nolvadex + Andriol.
In the bottom row you can see that the combination of Andriol and Nolvadex not only results in a higher testosterone level, but also in more FSH. So it is possible: to take androgens and at the same time stimulate the pituitary and the testes to produce more testosterone.
When a course of steroids is taken the testes usually shrink in size. But during this trial the volume of the testes actually increased. In the graph below the solid line represents the testes volume of the placebo group. The line with dots and dashes represents the Andriol group. The line with long dashes represents the Nolvadex group, and the line with short dashes represents the men who took Andriol + Nolvadex.
The men also produced more sperm as a result of the treatment, and the combination of Andriol and Nolvadex was most effective.
Source:Fertil Steril. 1997 Apr;67(4):756-62.
ergo-log
Saved the best to the last, a direct quotation from Power PCT Program by Dr. Michael Scally:
''clomid acts as an estrogen, rather than an antiestrogen, by sensitizing pituitary cells to the action of GnRH. Although tamoxifen is almost as effective as clomid in binding to pituitary estrogen receptors, tamoxifen has little or no estrogenic activity in terms of its ability to enhance the GnRH-stimulated release of LH. The estrogenic action of clomid at the pituitary represents a unique feature of this compound and that tamoxifen may be devoid of estrogenic activity at the pituitary level.''
If Clomid produces estrogenic action in the pituitary, doesn't this also mean it only serve to inhibit LH secretion?
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Originally Posted by Turkish Juicer;6397***
