winstrol and High b.p

[MuscleInk]

Bloat and gyno are the least important side effects. Lipids and BP issues are the most important in my book.

This has to be one of the most frequent errors people make about AIs (only taking to reduce bloat or gyno). People should spend a lot more time understanding the true risks of elevated estrogen.

Adex and letro will also negatively effect BP, aromasin less so.

[jimmyinkedup]

This has to be one of the most frequent errors people make about AIs (only taking to reduce bloat or gyno). People should spend a lot more time understanding the true risks of elevated estrogen.

Adex and letro will also negatively effect BP, aromasin less so.

Thank you for posting the bold. So often not understood, most in fact believe the opposite. It is so much the case with adex that astra zeneca was required to contact all physicians and have them inform any patients using adex of this potential side effect as it was not initially stated.

[MuscleInk]

Thank you for posting the bold. So often not understood, most in fact believe the opposite. It is so much the case with adex that astra zeneca was required to contact all physicians and have them inform any patients using adex of this potential side effect as it was not initially stated.

Yes! Anabolic Doc and I are PMing on this topic. I'm still amazed by the number of oncologists treating patients with AIs in adjuvant settings that are unaware of the effects of AIs on lipid metabolism.

A secondary (though lesser) concern is that over suppression of aromatase can effect hepatic mitochondrial function and lead to possible hepatic steatosis.

[jimmyinkedup]

Yes! Anabolic Doc and I are PMing on this topic. I'm still amazed by the number of oncologists treating patients with AIs in adjuvant settings that are unaware of the effects of AIs on lipid metabolism.

A secondary (though lesser) concern is that over suppression of aromatase can effect hepatic mitochondrial function and lead to possible hepatic steatosis.

This is a main area where a type 1 AI like exemestane seems to pull ahead of other AI options. Im actually writing on use of AI's on cycle at this very moment. Id certainly welcome some input / constructive criticism. If its cool Id like to share what I write with you before posting and get your thoughts. Or I can post it when its done and we can ALL tweek it. Whatever. The topic has my intent interest at the moment.

[MuscleInk]

This is a main area where a type 1 AI like exemestane seems to pull ahead of other AI options. Im actually writing on use of AI's on cycle at this very moment. Id certainly welcome some input / constructive criticism. If its cool Id like to share what I write with you before posting and get your thoughts. Or I can post it when its done and we can ALL tweek it. Whatever. The topic has my intent interest at the moment.

I think that would be an excellent topic Jimmy. The published literature is mixed and inconclusive and most are based on adjuvant cancer settings with AIs or aromatase knockout models.

I've been trying to get through more published literature on this topic for personal and professional reasons but a detailed summary or informed opinions would be very useful in this forum.

As I've said, some people are AIs only as needed to control bloat or gyno but there are many more reasons beyond vanity to include a good AI. As our discussion shows however, not all AIs are the same and some may be a safer choice than others wrt lipid metabolism and cardiac health.

[jimmyinkedup]

I think that would be an excellent topic Jimmy. The published literature is mixed and inconclusive and most are based on adjuvant cancer settings with AIs or aromatase knockout models.

I've been trying to get through more published literature on this topic for personal and professional reasons but a detailed summary or informed opinions would be very useful in this forum.

As I've said, some people are AIs only as needed to control bloat or gyno but there are many more reasons beyond vanity to include a good AI. As our discussion shows however, not all AIs are the same and some may be a safer choice than others wrt lipid metabolism and cardiac health.

It is an often misunderstood area in many ways. I often see people quoting AI effectiveness etc using #'s based on females when in fact it is very diff in males. The fatty liver aspect is tough to find concrete data in humans. Ive seen studies on mice and read in a google book the effect occurs in humans but am now trying to track the ref used in book to come up with some more concrete data in the form of an actual human study or even look for some case studies. As Sarge pointed out and as evidenced in the hrt forum here many docs that do prescribe trt are lacking in adequate knowledge in this area. AnwaySwifto did a write up and touched on some things - I wanna take it further.