Letro is overkill and as I said it WILL screw up his lipid metabolism and contribute to hyperlipidemia and hypercholesterolemia. Aromasin is a safer choice with Anastrozole as a secondary if aromasin is unavailable. Anastrozole works quickly and has a half life nearly 48 hours long. It will negatively effect lipids as well but isn't as bad as femara (letro).Originally Posted by drsblls