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Thread: Trenbolone causing Anorgasmia

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  1. #1
    Join Date
    May 2012
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    Nevada
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    Celexa did this to me last year. even 9 mo off of it I still had issues with anorgasmia. hell, when I was on test only and let estrogen get high, my prl increased enough to start lactating. Scary stuff.

    since discovering caber, life is great.
    Prami makes my adhd medication ineffective for some reason but also cures the anorgasmia

  2. #2
    Join Date
    Mar 2007
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    GTA, Canada
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    6,121
    Quote Originally Posted by BBJT200 View Post
    Celexa did this to me last year. even 9 mo off of it I still had issues with anorgasmia. hell, when I was on test only and let estrogen get high, my prl increased enough to start lactating. Scary stuff.

    since discovering caber, life is great.
    Prami makes my adhd medication ineffective for some reason but also cures the anorgasmia
    I am sure I have mentioned this before, but I too am prescribed dopamine producing and dopamine reuptake inhibiting ADD medication (Adderall). I have not noticed any significant reduction in the effectiveness of Adderall with Cabergoline use, although I can see how that would be an issue, considering prolactin antagonists such as Cabergoline and Pramipexole are dopaminergic compounds, which act as Dopamine receptor agonists. Essentially, they would attach to Dopamine receptors in place of actual Dopamine (much like Nolvadex vs Estrogen in breast tissue). The amphetamines in Adderall cause a surge of Dopamine output in the synapses between nerve cells, and also inhibit the reuptake of Dopamine. So, amphetamines essentially turn your dopamine output in your synapses from a garden hose into a full blast fire hose in addition to not allowing any of the Dopamine to be reuptaken into the nerve cells (for the duration of amphetamine use). The use of Dopaminergic compounds such as Prami and Caber may possibly reduce effectiveness of amphetamines by occupying Dopamine receptor sites in place of actual Dopamine, as I have already mentioned. However, I have not seen a reduction in the effects of the amphetamines from Adderall.

    Pramipexole may be a different story, as it acts as a Dopamine receptor agonist as well, but it seems to do so in other Dopamine receptors that Cabergoline does not. I cannot remember the name of these specific Dopamine receptor types that Prami works on that Cabergoline doesn't touch, i'd have to look up the clinical studies again and see. This is where the issue could be in reducing the effect of Dextroamphetamine and Levoamphetamine (the two amphetamines present in Adderall).

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