Hypothesis: "High Estrogen Environment Necessary For Maximum Tren Efficacy"

[Knockout_Power]

Wrong. I think the details expounded by the wikipedia exerpt are taken out of context by some readers... the truth is that when it talks about Progesterone's activity on receptors and how it affects Estrogen, the ER, and vice-versa, it deals with receptors in all kinds of tissues in the body (namely, breast tissue) - not muscle tissue. Progesterone can increase the ER's affinity for Estrogen, which is why some will become more sensitive to gyno while using 19-nor compounds such as Trenbolone or Nandrolone. I honestly think this whole topic is both splitting hairs as well as being taken totally out of context.

could also be my lack of the scientific knowledge behind all of this... and the original thought is a bit vague as to what it being co-related.

Would be interesting to know though since I may pick up the Tren sometime this year

[Atomini]

could also be my lack of the scientific knowledge behind all of this... and the original thought is a bit vague as to what it being co-related.
Would be interesting to know though since I may pick up the Tren sometime this year

Exactly. The hypothesis being proposed here is so utterly vague, I can't possibly fathom an experiment like this going in any intended direction towards a significant increase in muscle growth. If this could be performed in a properly controlled double-blind placebo study, we could definitively see if it does or doesn't make a difference. But with the knowledge we have thus far about the Estrogen-Progesterone-ER interaction in the body, we can say with a high degree of certainty that it isn't going to make that much of a difference. And then there's the question of all of this happening in humans. Yes, Estrogen plays a role in anabolism. But it isn't so profound as to say that excessive Estrogen levels will then result in even more growth. It is simply a necessary component with everything else in place. And then we have this hypothesis trying to link excessive Estrogen with Trenbolone resulting in greater muscle growth, and Trenbolone being a progestin somehow working with Estrogen to increase anabolism to an unknown/unstated extent (even though we know that the interactions with Progesterone and Estrogen when referred to in literature always refer to breast tissue and select other tissue, not muscle tissue... all the while the health risks of excessive Estrogen (ON TOP of the use of one of the harshes AAS ever created) are overlooked. Sounds like a vague, ugly situation to me.