"suicide AIs"

[PJS19]

Suicide inhibitors are generally a class of catalytic substrates that form covalent bonds to irreversibly inactivate an enzyme (such as aromatase). After the catalytic processes occur, the chemically reactive intermediate covalently binds to the enzyme and inhibits it. Suicide inhibitors are bound to the active site and prevent further reactions that could have occurred with the active site and its substrates.

Exemestane (aromasin) is an irreversible, aromatase inactivator. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation ("suicide inhibition"). By being structurally similar to aromatase, Exemestane permanently binds to the aromatase, preventing the enzyme from converting androgen into estrogen.

Your body will eventually manufacture more aromatase enzymes and your E2 will recover quickly when the AI is discontinued.

Thanks for that information. Do you think its strange that its been 2.5 months since discontinuation and I dont feel better? Or is that normal and its a timely process?

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Thanks for that information. Do you think its strange that its been 2.5 months since discontinuation and I dont feel better? Or is that normal and its a timely process?

its really hard to "feel" your estro level. symptoms are too general and non-specific.

and i think its really unusual(almost impossible) for your aromatase activity to be decreased after stopping aromasin 2 months ago.