Finasteride and DHT hardening effects

[Bonaparte]

finasteride works by blocking the conversion of test to DHT. this block is supposedly tissue-specific, only the scalp and prostate.

DHT-based AAS are already structurally similar to DHT. which means finas has totally no effect on them. the anabolic effects will still be present, and the hairloss sides is also unaffected.

I doubt Finasteride's effects are tissue-specific (because it really softens you up, raises estrogen, and increases gyno symptoms). But the 5a-r enzyme is most concentrated in certain tissues, so the finasteride will be there as well.

[agent88]

I have noticed with anavar (even though its already preconverted) it does not effect hardening effects..but can increase chances of gyno

[AD]

I doubt Finasteride's effects are tissue-specific (because it really softens you up, raises estrogen, and increases gyno symptoms). But the 5a-r enzyme is most concentrated in certain tissues, so the finasteride will be there as well.

there are different isoenzymes of the 5alpha-reductase. currently described as type I, II and III. these are found in different tissues in different concentrations.

finasteride only inhibit 2 of the 3 isoenzymes. the product information insert actually describes finas as a "specific inhibitor of type II 5ar". that is what i was trying to say when i said tissue-specificity. of course, when taken orally, finas is distributed throughout the body. i think it crosses the blood-brain barrier as well.