Raloxifene 2 month progress (bad) please read

[MuscleInk]

^ 60mg is a standard Evista dose. Unless I've lost my mind, there's nothing conclusive affecting bone. 60 to 80mg doses have been used in studies for 6 to 9 months with no adverse effects whatsoever.

Maybe I'm not up to date, but that's research from this year.

60mg is generally a clinically prescribed dose. We use 60mg and above for in situ breast adenocarcinomas. Raloxifen also carries a higher risk for stroke or thromboembolisms in people predisposed to those conditions. Among anabolic users where blood wok and lipid profiles are less than adequate, I'd strongly recommend 30mg or at the very least, front load 60 for 5 days and then cut it back. 30mg should be effective for gyno - depending on length of pre-existing gyno-mass.

Bone demineralization is seen around three months even in sporadic use at doses of 60-100mg (with higher doses clearly more problematic). Vitamin D, K, and calcium supplements are advised when using raloxifene daily for more than 14 days. I don't recall the exact pathway but I believe it effects a number of bone morphogenetic proteins such as FGF, PGE2, M-CSF, and PDGF.

[austinite]

60mg is generally a clinically prescribed dose. We use 60mg and above for in situ breast adenocarcinomas. Raloxifen also carries a higher risk for stroke or thromboembolisms in people predisposed to those conditions. Among anabolic users where blood wok and lipid profiles are less than adequate, I'd strongly recommend 30mg or at the very least, front load 60 for 5 days and then cut it back. 30mg should be effective for gyno - depending on length of pre-existing gyno-mass.

Bone demineralization is seen around three months even in sporadic use at doses of 60-100mg (with higher doses clearly more problematic). Vitamin D, K, and calcium supplements are advised when using raloxifene daily for more than 14 days. I don't recall the exact pathway but I believe it effects a number of bone morphogenetic proteins such as FGF, PGE2, M-CSF, and PDGF.

This is all news to me. I've researched this drug heavily. I guess not enough. Let me go back and see if I can find this info. I've used 80mg for 4 months with no ill effects. I'm on 60 mg right now. Scaring the crap out of me with all this.

If anyone has any docs on this please link. Off the top of my head, 100mg was used in 2 studies involving pubertal gynecomastia with zero side effects. Several studies on women were done with the interest of identifying any bone related issues, none were observed.

I'll report back once I research some more. Thanks for the advice, MI, if this is the case, we may need to update our threads. We've been pitching 60 to 80 for well over a year now in 100's of threads and stickies.

[MuscleInk]

This is all news to me. I've researched this drug heavily. I guess not enough. Let me go back and see if I can find this info. I've used 80mg for 4 months with no ill effects. I'm on 60 mg right now. Scaring the crap out of me with all this.

If anyone has any docs on this please link. Off the top of my head, 100mg was used in 2 studies involving pubertal gynecomastia with zero side effects. Several studies on women were done with the interest of identifying any bone related issues, none were observed.

I'll report back once I research some more. Thanks for the advice, MI, if this is the case, we may need to update our threads. We've been pitching 60 to 80 for well over a year now in 100's of threads and stickies.

Yes, I've seen the recommendations on here a few times. Bear in mind that many of the bone issues arise with cancer patients who have comorbidities, however I was discussing raloxifene vs tamoxifen for gyno management with a colleague last month and she said that raloxifene is certainly superior but doses of 60mg or above are not recommended for more than 2 weeks (3 at best) because of the potential risks. Personally I haven't seen these risks develop in patients but I've only treated a handful of young men for gyno with raloxifene and it was usually a 30 day course of 30mg/day.