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Thread: first cycle cellulitis?

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  1. #1
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    Quote Originally Posted by Derekjpapa
    Muscle ink I see you know a lot about infection and cellulitis, if I every get one or other and decide to self diagnose what antibiotic would be recommended ?? By what I read keflex. Sorry op for jumping In
    Yes sir. Had many of my own and treated more than I can remember. The popular first line therapy for most skin based infections is Cephalexin, a broad spectrum antibiotic that disables the peptidoglycan layer of bacteria causing degradation and destruction of bacteria. It is also an ideal choice for people who have known (or unknown) hypersensitivities to penicillins. Common problems with Cephalexin however include elevated liver enzymes (more than 90% of the drug survives first pass liver metabolism) nausea, dyspepsia, and drying out of connective tissue (which can be an issue among recreational and professional body builders).

    I personally prefer clindamycin because its more aggressive by attacking bacterial RNA and directly (not passively) kills the bacteria, BUT clindamycin is also harsh on the GI, will attack healthy stomach flora and can lead to serious GI issues including severe (potentially life threatening) diarrhea, dehydration, and electrolyte imbalances.

  2. #2
    Join Date
    Jan 2014
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    Quote Originally Posted by MuscleInk View Post
    The popular first line therapy for most skin based infections is Cephalexin
    Quote Originally Posted by MuscleInk View Post
    I personally prefer clindamycin because its more aggressive
    holy C. diff batman!

  3. #3
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    Quote Originally Posted by MODO

    holy C. diff batman!
    Yes, it can be a serious problem. That's why initial doses should be low. I've had optimal responses with clindamycin and bactrim but a handful of patients do present with GI syndromes and are immediately switched. That's why I do a ful work up and Hx with the patient to assess and prior GI issues that may contraindicate the use of clindamycin.

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