Anastrozole and low E2, how long to bounce back

[2Sox]

^^^ Never heard of DHEA converting to E2. Couldn't find any data on this. Someone please enlighten me.

And if you are watching your blood work and your DHEA-S is within range, I would say there is no issue.

[lovbyts]

^^^ Never heard of DHEA converting to E2. Couldn't find any data on this. Someone please enlighten me.

And if you are watching your blood work and your DHEA-S is within range, I would say there is no issue.

I have read it on here also but cant find it right now.

J Clin Endocrinol Metab. 1999 Jun;84(6):2170-6. [PMID: 10372727]

Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens.

Arlt W, Haas J, Callies F, Reincke M, Hubler D, Oettel M, Ernst M, Schulte HM, Allolio B.

The author makes a series of statements in which he cites the 1997 Labrie study (above), saying:

"Labrie et al. (19) administered a 20% DHEA cream in a daily dose of 10 mL for 14 days to a total of eight elderly men and women and found no significant increase in serum estrogen levels in either gender. These results differ from the findings of our study and those of Young et al. (18), but may be explained by the route of DHEA administration. As previously reported for transvaginal (20) and sublingual (13) administration of DHEA, Labrie et al. (18) also described an increased DHEA/DHEAS ratio after percutaneous DHEA administration compared to oral ingestion. Although many tissues contain sulfotransferases (21, 22) and may contribute to the peripheral conversion of DHEA to DHEAS, the hepatic sulfotransferase activity seems to be of predominant importance and is bypassed by nonoral DHEA administration due to avoidance of the hepatic first pass effect. An increased DHEA/DHEAS ratio may lead to a reduced conversion of DHEA to androgens and/or estrogens inside peripheral target cells, as DHEAS has a much longer half-life than DHEA, and it can be continuously converted back to DHEA by widespread tissue sulfatase activity (23, 24, 25, 26) followed by further bioconversion. Furthermore, avoidance of the first pass effect by nonoral administration of DHEA also leads to avoidance of hepatic aromatase and 5-reductase activities. This may explain a lack of conversion to estrogens in men as well as the reduced conversion to androgens in women after percutaneous DHEA administration (19). This view is supported by the data of Casson et al. (20), who found an increase in DHEA, but not in DHEAS and T, after transvaginal DHEA administration. Serum estrogen levels were not reported in this study (20).

Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens



http://press.endocrine.org/doi/full/...jcem.84.6.5789