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Thread: Blood test results back, looking for advice from the experts here. Please?

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  1. #1
    Join Date
    Feb 2012
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    Quote Originally Posted by 2Sox View Post
    MBOS,
    The most important things have already been mentioned but I'd like to add a few things. As has been said, abundant body fat makes for more E2 conversion so it's best to do everything you can to keep this conversion down. Of course, diet and exercise is the top of the list and, as others have suggested, keep you T at the lowest dose to be symptom free. I would also suggest that you consider more frequent dosing AND doing it SQ, to keep serum T spikes and consequently, E2 spikes, to the lowest levels possible. The lessons I learned here had me design my protocol for this very purpose. Other here follow a similar dosing schedule but mine is simple and straightforward: 16mg/day of T cyp along with 125iu hCG/day in the same syringe. Of course, everyone is different and what works for me won't necessarily work for you BUT in theory this is a very sound approach.

    From what I'm hearing, and what you've presented so far, you will need and AI sooner or later. I would suggest that you look into Aromasin/Exemestane as an AI, once you settle into your protocol and determine your need to keep your E2 under control. I've said this often but it bears repeating: Adex is VERY strong and a tough medication to get along with - as many will attest to. And it has a well known rebound effect which is extremely uncomfortable and difficult to deal with. This has been my experience. Anyway, I take 12.5mg Aromasin every 5.5-6 days and I don't even know I'm on an AI. I highly recommend it.
    What do you mean by a rebound effect and how would you stop it? Thanks

  2. #2
    Join Date
    Jan 2013
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    Quote Originally Posted by Bodacious View Post
    What do you mean by a rebound effect and how would you stop it? Thanks
    You described E2 as "kickin" your ass. Think of this feeling every time the Adex wears off and you need another dose. It's like you "crash" and it's not a good feeling. Your feet feel like lead, your thinking gets foggy and your eyes don't seem to follow your brain's orders. You do NOT have this feeling on Aromasin - ever. If you know how to dose Adex before this feeling hits you, you are very lucky. But most of the time catching this is very tricky and very often in trying to do so, you knock E2 very low. This has been my experience and from what I understand, the experience of others. Adex is a tough medication to get right. Since there is a much gentler AI available - Aromasin - IMO, it's just not worth it.

  3. #3
    Join Date
    Jun 2014
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    Quote Originally Posted by Bodacious View Post
    What do you mean by a rebound effect and how would you stop it? Thanks
    There's no need for the vast majority of those on TRT doses to worry about rebound. If it were a problem, the TRT forum would be peppered with threads about it. But I've gone back and read every post on 48 pages of threads, and this just isn't the case.

    And while it is true that a small number of people won't respond to Anastrozole (Arimidex, Liquidex, Dex), I suspect it's equally true that some people won't respond to Exemestane (Aromasin), which is hardly a reason to try Exemestane before Anastrozole.

    What is also true, and also a very good reason to not initiate treatment with Exemestane before attempting Anastrozole, is that a study with 7,576 participants comparing the two aromatase inhibitors head-to-head found that Exemestane was associated with more cases of acne than with Anastrozole, and with more cases of elevated levels of liver enzymes and bilirubin. And that was with an Anastrozole dose four times higher that what is commonly seen on the forum.

    No one should be saying that high E2 is good, but I think most of us are too quick to try getting on an AI schedule. I know that was true in my case.

    I read that a lot of guys here take 0.25mg of Anastrozole every four days so I tried the same routine, which turned out to be very effective in driving my E2 too low.

    After that, I went back to taking Anastrozole on an "as needed" basis, and kept track of the dates and amount taken. So far it seems to be working out at 0.25mg every six days; sometimes five, and sometimes 7. And of course, in my case, a few drinks will cause E2 to rise.

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