How much T warrants the usage of AI

[Proximal]

Did a Prolactinoma put you on TRT?
What's your free T number? Total T doesn't really matter at all.
Are you carrying excess body fat currently?

Yeah the Pituitary tumor was the culprit. Have been addressing this issue for 2 1/2 years. The Prolactin numbers have steadily dropped, annual MRIs have confirmed it is shrinking.

No one (endocrinology or HRT) has ever checked me for my free-T numbers. Not arguing here, but are you saying that my total T numbers aren't in any way reflective of my response to the TRT? My T has consistently been below 200 for years, and now at 1200, I am seeing changes in the appropriate things [muscle gains, fat loss, and of course, other things as well : ) ]

I am 57 and prior to initiating the TRT, I got my fat percentage down to approximately 15% with a strict paleo diet. I'm sure it is a bit lower now as the scale and the mirror (and my wife) aren't lying to me.

AI and E2 advice?????

[kelkel]

Yeah the Pituitary tumor was the culprit. Have been addressing this issue for 2 1/2 years. The Prolactin numbers have steadily dropped, annual MRIs have confirmed it is shrinking.

No one (endocrinology or HRT) has ever checked me for my free-T numbers. Not arguing here, but are you saying that my total T numbers aren't in any way reflective of my response to the TRT? My T has consistently been below 200 for years, and now at 1200, I am seeing changes in the appropriate things [muscle gains, fat loss, and of course, other things as well : ) ]

I am 57 and prior to initiating the TRT, I got my fat percentage down to approximately 15% with a strict paleo diet. I'm sure it is a bit lower now as the scale and the mirror (and my wife) aren't lying to me.

AI and E2 advice?????

Figured it was an adenoma when your doc put you on Caber. I'm curious what dose of Caber he has you on? I mention Free T as that is what works for you. Total T is really irrelevant. You can have a 10K total T level but if all your free T is bound it serves you no purpose. Only a small percentage of test is free in our systems. That said, don't get obsessed to much with numbers if you can avoid it. Use them as a guide along with how you feel.

AI use needs to be based on your E2 Sensitive Assay if at all possible for best accuracy. Standard estradiol is geared to women and not sensitive or accurate enough for men at lower levels. The difference between the two can be significant at times.

[Proximal]

Figured it was an adenoma when your doc put you on Caber. I'm curious what dose of Caber he has you on? I mention Free T as that is what works for you. Total T is really irrelevant. You can have a 10K total T level but if all your free T is bound it serves you no purpose. Only a small percentage of test is free in our systems. That said, don't get obsessed to much with numbers if you can avoid it. Use them as a guide along with how you feel.

AI use needs to be based on your E2 Sensitive Assay if at all possible for best accuracy. Standard estradiol is geared to women and not sensitive or accurate enough for men at lower levels. The difference between the two can be significant at times.

Thanks for your assistance - greatly appreciated! I started at .25 mg twice a week a couple years back, but the prolactin levels were not dropping quick enough for the endocrinologist. Then that was bumped to .5 mg twice a week till recently. However at the last check up, my prolactin levels climbed a little, not a lot, but I'm going to do 1.5 mg per week of the caber.

Gonna check my prolactin again in 3-4 weeks. If my levels are not lower, I might drop the Sermorelin. I'm also going to request that E2 Sensitive Assay and then figure what I need to do with the Anastrozole overall. Right now, I'm going to drop that to .25 mg, twice per week till my blood test.

Again, appreciate your help - this forum has been fantastic, you guys are great, thanks!