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  1. #1
    Quote Originally Posted by GirlyGymRat View Post
    I have no experience using other then Clen. I am not w fan of Clen. I can deal with the shakes. Writing was troublesome. Ppl at work noticed. It's not gonna shred you. It's for the last 5 lbs IMHO. Diet is far more effective. But I did say I HATE Clen. Lol.
    Propranolol (beta blocker) for the shakes. You still get all of the sympathomimetic benefits of Clen (+ increased respiratory for blood oxygenation benefits) without the shakes. I've run up to 160mcg/day of Clen while on AAS and it's alllllll about the beta blockers for making the shakes manageable. It's the same medication that surgeons take. Most doctors will prescribe it without much debate if you go in with shaky hands or hyperhydrosis (sweaty hands), etc.

    The last 5lbs... yeah Clen is for more than that. I dropped ~20lbs last summer in 1.5 months while taking Clen, Vyvanse (lysine-bond time release amphetamine - like adderall), Spironolactone (for diuretic), and changing diet. 192 to 170. Then lost more before starting my last AAS cycle in August where I ran Clen and Insulin at the same time (omg the pump) - you remember that thread I'm sure.

    Clen is a miracle I love that shit. YMMV. But definitely diet is always always always important no matter what the goal is.
    Last edited by ambernightly; 02-04-2016 at 01:26 PM.

  2. #2
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    Quote Originally Posted by ambernightly View Post
    Propranolol (beta blocker) for the shakes. You still get all of the sympathomimetic benefits of Clen (+ increased respiratory for blood oxygenation benefits) without the shakes. I've run up to 160mcg/day of Clen while on AAS and it's alllllll about the beta blockers for making the shakes manageable. It's the same medication that surgeons take. Most doctors will prescribe it without much debate if you go in with shaky hands or hyperhydrosis (sweaty hands), etc.
    Unfortunately, Beta-1 agonism from clen at higher doses is responsible for much of its effects. It is only truly selective for B-2 at very low doses.
    So by taking propranolol, you're blocking all the B-1 activity (which is very effective for weight loss) and relying on the B-2 effects, which are milder. I'm not crazy about the idea of taking 2 potent drugs to mostly cancel each other out (taking a low dose of clen would be simpler and more fool-proof), but I'll admit that the idea is interesting and has its merits (mostly because it should be blood pressure friendly, since you're cancelling out all adrenergic pressor activity).
    Last edited by Bonaparte; 02-04-2016 at 03:50 PM.

  3. #3
    Quote Originally Posted by Bonaparte View Post
    Unfortunately, Beta-1 agonism from clen at higher doses is responsible for much of its effects. It is only truly selective for B-2 at very low doses.
    So by taking propranolol, you're blocking all the B-1 activity (which is very effective for weight loss) and relying on the B-2 effects, which are milder. I'm not crazy about the idea of taking 2 potent drugs to mostly cancel each other out (taking a low dose of clen would be simpler and more fool-proof), but I'll admit that the idea is interesting and has its merits (mostly because it should be blood pressure friendly, since you're cancelling out all adrenergic pressor activity).
    mmm, good point... I only take prop if I'm pre-hypertensive from Clen - prefer lower doses whenever possible (which also seems to be body weight dependent but isn't easily equated to a linear scale). I was 30lbs heavier when I was doing >150mcg doses (and that only at last 3 days of the two week clen cycle). Now I can't get above 75mcg without it feeling kinda awful (though maybe it's to do with thyroid med combo?). Going to read more about how Clonidine works with receptors in the presence of Clen - I have a bunch of that on hand... then was considering buying some manner of ACE Inhibitor to try out but I don't know where to start on those yet, still researching. oooh the fun with my home pharmacy never ends!

    Quote Originally Posted by megang View Post
    What blood work should I get?
    These are the ones I always ask for


    • Total & Free testosterone (not serum only, need total and free)
    • DHT (dihydrotestosterone)
    • Estradiol (E2 - estrogen. keep in mind this fluctuates very much during the menstrual cycle, so timing of the blood test needs to take that into account when it's being used as a decision making statistic. strive to get blood work done at the same time of the menstrual cycle each time.)
    • DHEA (precursor to the aboves)
    • Prolactin (progesterone related)
    • TSH and/or T3 (thyroid info)
    • Lipid panel (need to know cholesterol and other aspects)
    • Complete Metabolic Panel (so much useful info)
    • CBC w/ automated differential (complete blood cell count)


    Been wanting to add these to my consistent list but then I feel like I don't want to pay extra....

    • SHBG (see note below)
    • Aldosterone (because I'm curious...)
    • Progesterone (self explanatory)


    Testosterone and estradiol circulate in the bloodstream, bound mostly to SHBG and to a lesser extent serum albumin and corticosteroid-binding globulin (CBG) (AKA transcortin). Only a very small fraction of about 1-2% is unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor. SHBG inhibits the function of these hormones. Thus, bioavailability of sex hormones is influenced by the level of SHBG. The relative binding affinity of various sex steroids for SHBG is dihydrotestosterone (DHT) > testosterone > androstenediol > estradiol > estrone.[3] DHEA is weakly bound to SHBG as well, but DHEA-S is not.[3] Androstenedione is not bound to SHBG either, and is instead bound solely to albumin.[4]
    Click image for larger version. 

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  4. #4
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    Quote Originally Posted by ambernightly View Post
    mmm, good point... I only take prop if I'm pre-hypertensive from Clen - prefer lower doses whenever possible (which also seems to be body weight dependent but isn't easily equated to a linear scale). I was 30lbs heavier when I was doing >150mcg doses (and that only at last 3 days of the two week clen cycle). Now I can't get above 75mcg without it feeling kinda awful (though maybe it's to do with thyroid med combo?). Going to read more about how Clonidine works with receptors in the presence of Clen - I have a bunch of that on hand... then was considering buying some manner of ACE Inhibitor to try out but I don't know where to start on those yet, still researching. oooh the fun with my home pharmacy never ends!
    Clonidine decreases all sympathetic NS activity by causing norepinephrine reuptake (through Alpha 2 agonism). So it is basically the anti-caffeine in its effects. You wouldn't want that if you're trying to lose weight and taking clen. But an ACE inhibitor would be fine for treating just the hypertension without messing up any of the other effects. You can't really go wrong with lisinopril (so long as you aren't in the 15% of people who experience a persistent dry cough from ACE inhibitors). Ramipril is more potent and fast-acting, but needs to be dosed twice daily.

  5. #5
    Quote Originally Posted by Bonaparte View Post
    Clonidine decreases all sympathetic NS activity by causing norepinephrine reuptake (through Alpha 2 agonism). So it is basically the anti-caffeine in its effects. You wouldn't want that if you're trying to lose weight and taking clen. But an ACE inhibitor would be fine for treating just the hypertension without messing up any of the other effects. You can't really go wrong with lisinopril (so long as you aren't in the 15% of people who experience a persistent dry cough from ACE inhibitors). Ramipril is more potent and fast-acting, but needs to be dosed twice daily.
    very interesting, great information. will be ordering up ACEs next! also noticed that Propranolol can inhibit T3 activity/functionality, so that's another consideration with weight loss and general bodybuilding.

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