TRT without hcg.

[hammerheart]

Trial and error, you know.

[IncreaseMyT]

Trial and error, you know.

Are you sure thats what it is? In truth all of our patients start at 500 IU 2 times per week.

[hammerheart]

Are you sure thats what it is? In truth all of our patients start at 500 IU 2 times per week.

What's the difference?

Given the half life of HCG is about 48h an eod protocol seems more reasonable (provided one has the patience). Personally I have no problem pinning ED.

500IU two times a week is 1000IU/w, the same as 250IU EOD, or 150 ED.

[IncreaseMyT]

What's the difference?

Given the half life of HCG is about 48h an eod protocol seems more reasonable (provided one has the patience). Personally I have no problem pinning ED.

500IU two times a week is 1000IU/w, the same as 250IU EOD, or 150 ED.

Well HCG has a biphasic pattern. It stimulates T initially and then the testes go into a refractory period, 72 hours later releasing more T from the same shot. So technically you could do once per week.

I am not sure the schedule matters but personally I am also not sure if less than 500IU in one dose does much to override suppression.

Let me know if that makes sense.

[hammerheart]

Well HCG has a biphasic pattern. It stimulates T initially and then the testes go into a refractory period, 72 hours later releasing more T from the same shot. So technically you could do once per week.

I am not sure the schedule matters but personally I am also not sure if less than 500IU in one dose does much to override suppression.

Let me know if that makes sense.

I think the question here is what we are using HCG for. I already got enough T from TRT, so I don't need the Leydigs to release it . What I want from HCG is 1) to prevent further atrophy 2) to restore physiological levels of T precursors 3) to increase brain pregnenolone.

If it's making me irritable I suppose the boost of inhibitory neurosteroids (I've already explained this elsewhere) saturated the GABA-A receptor potential, so I'm probably taking more than needed.

[FakeLove]

Well HCG has a biphasic pattern. It stimulates T initially and then the testes go into a refractory period, 72 hours later releasing more T from the same shot. So technically you could do once per week.

I am not sure the schedule matters but personally I am also not sure if less than 500IU in one dose does much to override suppression.

Let me know if that makes sense.

There's one study available that suggests that even 125IU every other day provides results statistically not significant compared to the baseline in context of suppression. Baseline was maintained at 250IU eod and it increased with 500IU eod. I know many examples who have restored fertility with 250IU eod protocol, but of course there must be individual variance in this.

For OP: I've had a stable testosterone only protocol for almost two years now, and now for fertility purposes added HCG with 125IU ed. It blew my estrogen production through the roof instantly. To maintain my optimal estrogen level with HCG I need a triple AI dosage compared to the testosterone alone. We've had a discussion of the topic on the other forum and it's quite clear that AI's aren't very efficient to control the increased estrogen production caused by HCG. So I'd say for some it just requires heavy AI dosages to keep estrogen in check to maintain a good mood and function. When I'm on top of the AI dosage I'm all good, but if I try to reduce hell breaks loose.