My Nebido Blog

[AR's King Silabolin]

You needed to inject the 4ml in same spot.

It will have very different release in two separate places.

I guess pseudo-equilibrium is the same when u hit the same muscle.

Stil dont see why release should differ.

Not arguing to be stubborn. Dont understand why yet.

[Mr.BB]

I guess pseudo-equilibrium is the same when u hit the same muscle.

Stil dont see why release should differ.

Not arguing to be stubborn. Dont understand why yet.

You need to understand how the hormone gets release from the ester... Ok, maybe first you need to understand what is a esterified hormone.

An hormone attached to an ester its not active, and the bigger the ester the less water soluble it is. What is called ester is just a kind of "tail" of carbon atoms attached, the longer the ester the more carbons has all attached. For example proprianate ester is a 3 carbons chained together, undecanoate has an 11 carbon atoms chain.
Like I said before the bigger the carbon chain the lower the water solubility forcing the hormone+ester to remain deposited at injection site.

The hormone gets released by the action of 2 enzymes that remove the carbon chain ester, atom by atom, so the bigger the chain the slower it gets released to the blood stream to become active.

So if you have a deposit you will have this 2 enzymes "attacking" the esters to release the hormone, if you have 2 deposits you will have a larger surface area where the enzymes can attack.

There are other variables involved, but I think this makes a pretty picture of what happens.

If you inject in 2 places (or more), you will basically have a higher release rate, but of course it will not last the period of time it has been studied to work.

[AR's King Silabolin]

You need to understand how the hormone gets release from the ester... Ok, maybe first you need to understand what is a esterified hormone.

An hormone attached to an ester its not active, and the bigger the ester the less water soluble it is. What is called ester is just a kind of "tail" of carbon atoms attached, the longer the ester the more carbons has all attached. For example proprianate ester is a 3 carbons chained together, undecanoate has an 11 carbon atoms chain.
Like I said before the bigger the carbon chain the lower the water solubility forcing the hormone+ester to remain deposited at injection site.

The hormone gets released by the action of 2 enzymes that remove the carbon chain ester, atom by atom, so the bigger the chain the slower it gets released to the blood stream to become active.

So if you have a deposit you will have this 2 enzymes "attacking" the esters to release the hormone, if you have 2 deposits you will have a larger surface area where the enzymes can attack.

There are other variables involved, but I think this makes a pretty picture of what happens.

If you inject in 2 places (or more), you will basically have a higher release rate, but of course it will not last the period of time it has been studied to work.

This makes sense. Very logical. If two deposits i will feel better the first weeks and worse the last weeks.
So now my test check at week 5 migth be too high related to the value the developers were aiming for.

Hm. It would be interesting if someone had real life bloodtest facts at week 6 with these two different methods.
Maybe you remember yours BB...then we can compare if mine is significantly out of order. Given its not that more other factors.

Good explanation. Didnt see it that way. Thanks.

But...maybe its a good thing to start the Nebido journey with two spots then. If you are very low at start. So u not will be tempted to kickstart with test p. Specially if the doc agrees on the booster.

[Mr.BB]

This makes sense. Very logical. If two deposits i will feel better the first weeks and worse the last weeks.
So now my test check at week 5 migth be too high related to the value the developers were aiming for.

Hm. It would be interesting if someone had real life bloodtest facts at week 6 with these two different methods.
Maybe you remember yours BB...then we can compare if mine is significantly out of order. Given its not that more other factors.

Good explanation. Didnt see it that way. Thanks.

But...maybe its a good thing to start the Nebido journey with two spots then. If you are very low at start. So u not will be tempted to kickstart with test p.

I havent done any hormone BW at week 5, only done after 7 months or so. Im not too worried about numbers like I told you before.

I cant even find a lab with LC MS method, whats the point of knowing a number if it can be 20% higher or lower? As long as I feel good its fine.

(of course I measure other bw numbers cholesterol, H&H, liver...)